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US 9,539,281 B2Granted
Lipid-containing PSA compositions, methods of isolation and methods of use thereof
AssigneeThe Brigham and Women's Hospital, Inc.
InventorsDennis L. Kasper, Deniz Erturk-Hasdemir, Barbara Reinap
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Abstract
The invention provides compositions comprising lipid-conjugated forms of capsular polysaccharide A (PSA) from B. fragilis (referred to herein as PSA-LT), methods of isolating such forms and of making such compositions and methods for their use.
Claims16
A pharmaceutical composition comprising:
- an isolated lipidated polysaccharide A (PSA) comprising a PSA polysaccharide covalently conjugated to a lipid, and
- a pharmaceutically-acceptable carrier or excipient,
- wherein the composition is suitable for administration to a human.
A pharmaceutical composition comprising isolated lipidated polysaccharide A (PSA) comprising polysaccharide A (PSA) covalently conjugated to a lipid.
A pharmaceutical composition formulated for oral administration, the composition comprising:
- a preparation of an isolated polysaccharide whose structure comprises a tetrasaccharide repeating unit as set forth below:
- which preparation comprises the isolated polysaccharide conjugated to a non-LPS lipid;
- and
- a pharmaceutically acceptable carrier;
- wherein the composition is essentially free of a B.fragilis nucleic acid and/or protein.
2 more elements
Dependencies are inferred from the claim text.