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US 9,539,278 B2Granted
Preparation for use of aspartate and vitamin B12 or biotin for regulating ketone bodies
AssigneeN.V. Nutricia
InventorRobert Johan Joseph Hageman
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AssigneeN.V. Nutricia
InventorRobert Johan Joseph Hageman
Estimating the term…
It has been found that high amounts of aspartate equivalents in combination with vitamin B12 and/or biotin, especially in relative absence of glutamate equivalents, improve the metabolism of ketobodies and/or lactate in a mammal's body, especially in diseased or traumatic conditions. As a result, levels of ketobodies and lactate can be decreased and unphysicologically high acidity normalised. Thus, it is an object of the invention to provide an enteral nutritional or a pharmaceutical composition for the treatment and/or prevention of disturbed ketone and lactate metabolism, i.e. elevated concentrations of ketone bodies, lactate and/or other organic acids and/or insufficient pH homeostasis, especially elevated concentrations of ketone bodies and/or lactate, in a mammal's blood, wherein the composition comprises high amounts of aspartate equivalents in combination with vitamin B12 and/or biotin, preferably in relative absence of glutamate equivalents.
An enteral nutritional composition comprising a protein fraction and a carbohydrate fraction providing 15-22 en % and 25-50 en %, respectively, wherein the protein fraction comprises at least 10.8 wt % of aspartate equivalents, based on the total weight of the protein fraction, wherein the protein fraction comprises a first aspartate-rich source selected from a protein, a protein concentrate, isolate or hydrolysate and free aspartate equivalents, and a second aspartate-rich source different form the first source, and wherein the composition further comprises at least one of vitamin B12 and biotin.
An enteral nutritional composition comprising a protein fraction and a carbohydrate fraction providing 15-22 en % and 25-50 en %, respectively, wherein the protein fraction comprises at least 12.0 wt % of aspartate equivalents, based on the total weight of the protein fraction, wherein the protein fraction comprises at least two proteins, and wherein the proteins comprise a combination of a protein from plant origin and a protein from animal origin, and wherein the composition further comprises at least one of vitamin B12 and biotin.
A method for treatment of diabetes, comprising administering to a mammal in need thereof a composition comprising:
A method for treatment of metabolic disorders associated with elevated concentrations of ketone bodies, lactate and/or organic acids and/or insufficient pH homeostasis in a mammal's blood, comprising administering to a mammal in need thereof a composition comprising:
Dependencies are inferred from the claim text.