Compositions and methods for treating viral infections
AssigneeSpring Bank Pharmaceuticals, Inc.
InventorsRadhakrishnan P. Iyer, Seetharamaiyer Padmanabhan
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Abstract
The present invention provides compositions methods for treating susceptible viral infections, especially hepatitis C viral (HCV) infections as well as co infections of HCV with other viruses such as HBV and/or HIV. In one embodiment, the present invention provides compositions having the formula (I) and their use in treating viral infections: or a pharmaceutically acceptable salt, ester, stereoisomer, tautomers, solvate, prodrug, or combination thereof.
Claims17
A method of treating HCV infection in a patient, the method comprising administering to the patient in need of such treatment an effective amount of a compound selected from the group consisting of compound 4, compound 6m, or compound 7:
- or a pharmaceutically acceptable salt, ester, stereoisomer, tautomer, solvate, or combination thereof.
A method of treating HCV infection in a patient, the method comprising administering to the patient in need of such treatment an effective amount of a compound of formula A1:
- or a pharmaceutically acceptable salt, ester, stereoisomer, tautomer, solvate, or combination thereof, wherein V, M, R10, and R11 are delineated for compounds 1-8 in Table 1:
- TABLE 1
- compound
- No.
- R
- X1
- R3
- R4
- 1
- absent
- H
- H
- 2
- O
- H
- H
- 3
- absent
- H
- H
- 4
- O
- H
- H
- 5
- O
- C(O)Ph
- H
- 6
- O
- H
- C(O)Ph
- 7
- absent
- H
- H
- 8
- O
- H
- H
- and the compound is administered in combination with a second anti-HCV agent selected from a polymerase inhibitor and a protease inhibitor.
Dependencies are inferred from the claim text.