Methods, compositions, and formulations for preventing or reducing adverse effects in a patient
AssigneePericor Therapeutics, Inc.
InventorDennis T. Mangano
Life of this patent
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Abstract
The present invention provides methods, compositions, formulations, and kits related to acadesine, or a prodrug, analog, or salt thereof, and/or a blood clotting inhibitor for preventing or reducing adverse side effects in a patient. The type of patient that may benefit includes a patient with decreased left ventricular function, a patient with a prior myocardial infarction, a patient undergoing non-vascular surgery, or a fetus during labor and delivery.
Claims12
A method of treating a patient with decreased left ventricular function having an ejection fraction that is less than 30%, comprising administering to said patient an effective amount of an AICA riboside analog;
- wherein the AICA riboside analog is 5-amino-1-β-D-(5-benzylamino-5-deoxy-1-β-D-ribofuranosyl)imidazole-4-carboxamide or a salt thereof;
- wherein, prior to the administration, the patient has decreased left ventricular function as measured by an ejection fraction that is less than 30%, and following the administration, the patient has improved left ventricular function.
Dependencies are inferred from the claim text.