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US 9,539,273 B2Granted
Targeted delivery of anti-fungal agents
AssigneeEDH Biotech Corp
InventorsThomas Meehan, Quyen Ong
Life of this patent
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Abstract
The present application discloses a targeting composition that actively targets chitin-like substances, such as those found in fungi, protists, arthropods, Alzheimer's plaques, etc. Methods are disclosed for preparation of chitin-targeted drug delivery vehicles composed of the targeting composition and one or more bioactive compounds.
Claims12
A chitin targeting agent comprising the following structure:
- wherein R4a, R4b, and R6a are independently selected from Cl, amino, or hydroxy, the last two of which are optionally substituted by alkyl, alkylamino, alkylhydroxy, alicyclic, heterocyclic, aryl, and alkyl- or arylsulfonic acid, where each of the optional substituents may further be optionally substituted by one or more groups selected from the group consisting of hydroxy and amino,
- wherein R6b is linked to phospholipid-PEGn, where the number of PEG units, n, is about 10-250, phospholipid, or dendrimer (G3-G10),
- wherein the linker is composed of PEG, alkyl, heteroalkyl, heterocyclic, or aryl, and pharmaceutically acceptable salts thereof.
Dependencies are inferred from the claim text.