Methods for decreasing the incidence of necrotizing enterocolitis in infants, toddlers, or children using human milk oligosaccharides
AssigneeAbbott Laboratories
InventorsJoMay Chow, Steven R. Davis, Rachael Buck, Geralyn O. Duska-McEwen, Hawley K. Linke
Life of this patent
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Abstract
Disclosed are methods of reducing the incidence of necrotizing enterocolitis in an infant, toddler, or child using nutritional compositions including human milk oligosaccharides. The nutritional compositions including the human milk oligosaccharides are effective in reducing inflammation and the incidence of inflammatory diseases.
Claims18
A method of reducing the incidence of necrotizing enterocolitis in an infant, toddler, or child, the method comprising administering to an infant, toddler, or child in need thereof, a nutritional composition comprising human milk oligosaccharides selected from the group consisting of 2′-fucosyllactose, lacto-N-neotetraose, and combinations thereof in a total amount of from about 0.001 mg/mL to about 20 mg/mL.
A method of reducing the incidence of necrotizing enterocolitis in an infant, toddler, or child, the method comprising administering to an infant, toddler, or child in need thereof a nutritional composition comprising 6′-sialyllactose, 2′-fucosyllactose, and lacto-N-neotetraose wherein the 6′-sialyllactose, 2′-fucosyllactose, and lacto-N-neotetraose are present in a total amount of from about 0.001 mg/mL to about 20 mg/mL.
A synthetic formula for improving the feeding tolerance of an infant, toddler, or child, the synthetic formula comprising from about 0.001 mg/mL to about 20 mg/mL of an oligosaccharide blend and an emulsifying agent, wherein the oligosaccharide blend comprises a first oligosaccharide selected from the group consisting of a fructooligosaccharide, a galactooligosaccharide, lacto-N-neotetraose, 2′-fucosyllactose, and combinations thereof;
- a second oligosaccharide selected from the group consisting of 3′-sialyllactose, 6′-sialyllactose, and combinations thereof;
- and a third oligosaccharide selected from the group consisting of inulin, a gum, polydextrose, and combinations thereof.
A method of improving the feeding tolerance of an infant, toddler, or child in need thereof, the method comprising administering to the infant, toddler, or child a nutritional composition comprising from about 0.001 mg/mL to about 20 mg/mL of an oligosaccharide blend, wherein the oligosaccharide blend comprises a first oligosaccharide selected from the group consisting of a fructooligosaccharide, a galactooligosaccharide, lacto-N-neotetraose, 2′-fucosyllactose, and combinations thereof;
- a second oligosaccharide selected from the group consisting of 3′-sialyllactose, 6′-sialyllactose, and combinations thereof;
- and a third oligosaccharide selected from the group consisting of inulin, a gum, polydextrose, and combinations thereof.
Dependencies are inferred from the claim text.