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US 9,539,268 B2Granted
Therapeutic compositions comprising imidazole and imidazolium compounds
AssigneeAntecip Bioventures II LLC
InventorHerriot Tabuteau
Life of this patent
Estimating the term…
Abstract
Therapeutic compositions comprising substituted imidazole or imidazolium compounds may be used for a number of medical purposes, such as treatment of undesirable conditions or diseases, including disease or conditions related to bone, cancer, and/or pain.
Claims30
A method of treating arthritis comprising orally administering a dosage form to a mammal in need thereof, wherein the dosage form comprises:
- (Ion B) in a salt form, in an amount that is less than 0.1% w/w and greater than 0% w/w;
- or
- (Ion C) in a salt form, in an amount that is less than 0.1% w/w and greater than 0% w/w;
- wherein each A is independently an acidic functional group;
- wherein, if present, the bioavailability of Compound A in the dosage form is from about 1.1% to about 4%.
2 more elements
A method of treating arthritis comprising orally administering a dosage form to a human being suffering from arthritis, wherein the dosage form comprises:
- a) zoledronic acid in a salt or an acid form;
- or
- b) one of the following:
- 1) zoledronic acid in a salt or an acid form and
- (Ion 1) in a salt form, in an amount that is less than 0.1% w/w and greater than 0% w/w;
- or
- 2) zoledronic acid in a salt or an acid form and
- (Ion 2) in a salt form, in an amount that is less than 0.1% w/w and greater than 0% w/w;
- or
- 3) zoledronic acid in a salt or an acid form and a combination of Ion 1 in a salt form, in an amount that is less than 0.1% w/w and greater than 0% w/w, and Ion 2 in a salt form, in an amount that is less than 0.1% w/w and greater than 0% w/w;
- wherein the dosage form is free of therapeutically active agents that are not zoledronic acid in a salt or an acid form, Ion 1 in a salt form, or Ion 2 in a salt form;
- wherein any amount in % w/w is based upon the total weight of zoledronic acid in a salt or an acid form, Ion 1, Ion 2, and any corresponding counter ions;
- and
- wherein the bioavailability of zoledronic acid in the dosage form is about 1.1% to about 4%.
11 more elements
A pharmaceutical dosage form for oral administration comprising:
- a) zoledronic acid in a salt form;
- or
- b) one of the following:
- 1) zoledronic acid in a salt or an acid form and
- (Ion 1) in a salt form, in an amount that is less than 0.1% w/w and greater than 0% w/w;
- 2) zoledronic acid in a salt or an acid form and
- (Ion 2) in a salt form, in an amount that is less than 0.1% w/w and greater than 0% w/w;
- or
- 3) zoledronic acid in a salt or an acid form and a combination of Ion 1 in a salt form, in an amount that is less than 0.1% w/w and greater than 0% w/w, and Ion 2 in a salt form, in an amount that is less than 0.1% w/w and greater than 0% w/w;
- wherein the dosage form is free of therapeutically active agents that are not zoledronic acid in a salt or an acid form, Ion 1 in a salt form, or Ion 2 in a salt form;
- wherein any amount in % w/w is based upon the total weight of zoledronic acid in a salt or an acid form, Ion 1, Ion 2, and any corresponding counter ions;
- and
- wherein the bioavailability of zoledronic acid in the dosage form is about 1.2% to about 4% in a human being.
10 more elements
Dependencies are inferred from the claim text.