Topical minocycline compositions and methods of using the same

A method comprising applying to a keratinized skin surface location of a subject a topical minocycline composition comprising porous, ceramic calcium phosphate particles having a pore size ranging from 2 nm to 100 nm and loaded with a minocycline active agent, wherein the amount of minocycline active agent associated with the particles ranges from 0.1 to 100 mg/g and the composition is a formulation configured to be applied to a keratinized skin surface location of a mammal and is chosen from a lotion, gel, cream and ointment, and further wherein the topical minocycline composition exhibits reduced fluorescence as compared to a control.

A method of treating acne in a subject, the method comprising:

• applying to a keratinized skin surface location of a subject known to have acne a topical minocycline composition comprising porous calcium phosphate particles having a pore size ranging from 2 nm to 100 nm and loaded with a minocycline active agent, wherein the amount of minocycline active agent associated with the particles ranges from 0.1 to 100 mg/g and the composition is a formulation configured to be applied to a keratinized skin surface location of a mammal and is chosen from a lotion, gel, cream and ointment, and further wherein the topical minocycline composition exhibits reduced fluorescence as compared to a control.