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US 9,539,265 B2Granted
Pharmaceutical formulation containing glycosaminoglycan
AssigneeAihol Corporation
InventorPao-Ho Chang
Life of this patent
Estimating the term…
Abstract
A pharmaceutical formulation containing a glycosaminoglycan is provided. In this pharmaceutical formulation, a glycosaminoglycan layer surrounding a drug layer is used to improve the treatment efficiency of enteric diseases.
Claims17
A pharmaceutical formulation containing at least a pellet,
- the pellet comprising:
- a core comprising a pharmaceutically acceptable inert material;
- a drug layer surrounding the core, wherein the drug layer comprises a therapeutically effective amount of a drug for treating an enteric disease;
- a glycosaminoglycan layer directly surrounding the drug layer, wherein the glycosaminoglycan layer comprises a glycosaminoglycan;
- an isolation layer surrounding the glycosaminoglycan layer, wherein the isolation layer comprises a hydrophobic polymer, which is dissolved at a pH value of at least 5.5;
- and
- an enteric coating layer surrounding the isolation layer, wherein the enteric coating layer comprises an enteric polymer, which is dissolved at a pH value of at least 6.8.
4 more elements
A pharmaceutical formulation containing at least a pellet, the pellet comprising:
- a core comprising a pharmaceutically acceptable inert material;
- a drug layer surrounding the core, wherein the drug layer comprises a therapeutically effective amount of a drug for treating an enteric disease, and the drug is selected from the group consisting of mesalamine, laxatives, anti-diarrheals, glucocorticoids, antimicrobials, immunosuppressants, chemotherapeutics, anti-cancer drugs, peptides, proteins, cardiovascular drugs, psychotropic drugs, H2-blockers, antiasthmatic agents, antihistamines, steroid, non-steroid anti-inflamatory drug (NSAID), antibiotic, anti-inflammatory, and any derivatives thereof;
- a glycosaminoglycan layer directly surrounding the drug layer, wherein the glycosaminoglycan layer comprises a glycosaminoglycan, and the glycosaminoglycan is hyaluronic acid or a salt thereof, chondroitin sulfates, heparin sulfate, heparin, keratan sulfate, or dermatan sulfate;
- and
- an enteric coating layer surrounding the glycosaminoglycan layer, wherein the enteric coating layer comprises an enteric polymer, which is dissolved at a pH value of at least 6.8.
2 more elements
Dependencies are inferred from the claim text.