Dihydro-benzo-oxazine and dihydro-pyrido-oxazine derivatives

A compound of formula (I)

• or a salt thereof, wherein
• Y is selected from O or NH;
• V is selected from CR5 or N;
• W is selected from CH2, or O;
• U is selected from N or CH;
• Q is selected from N or CR6;
• wherein U and Q are not both N;
• R1 is selected from phenyl, pyridyl, pyrimininyl, pyrazinyl, pyridazinyl, 1,2,3-triazinyl, 1,2,4-triazinyl, 1,3,5-triazinyl, or
• —X—R4
• wherein X is selected from C(O), S(O)2 or CH2
• and
• R4 is selected from C1-C8-alkyl, halo-C1-C8-alkyl, hydroxy-C1-C8-alkyl, C1-C8-alkoxy-C1-C8-alkyl, cyano-C1-C8-alkyl, N,N-di-C1-C4-alkyl-amino-C1-C8alkyl, C1-C4-alkyl-sulfonyl-C1-C8-alkyl, phenyl, heterocyclyl, heterocyclyl-oxy, heterocyclyl-C1-C8-alkyl, C3-C12-cycloalkyl, C3-C12-cycloalkyl-oxy, C3-C12-cycloalkyl-C1-C8-alkyl, heteroaryl, heteroaryl-oxy, heteroaryl-C1-C8-alkyl, hydroxy, C1-C8-alkoxy, amino, N—C1-C8-alkyl-amino or N,N-di-C1-C8-alkyl-amino,
• wherein C1-C8-alkyl in N—C1-C8-alkyl-amino and in N,N-di-C1-C8-alkyl-amino may be unsubstituted or substituted by halogen, hydroxy or C1-C4-alkoxy,
• wherein C3-C12-cycloalkyl in C3-C12-cycloalkyl and in C3-C12-cycloalkyl-C1-C8-alkyl may be unsubstituted or substituted by 1-5 substituents selected from halogen, hydroxy or C1-C4-alkoxy;
• wherein ‘heterocyclyl’ is a 3 to 7 membered saturated or partially unsaturated monocyclic ring system containing 1 to 3 heteroatoms selected from N, O or S, each of which is unsubstituted or substituted by 1-5 substituents selected from oxo, halogen, C1-C8-alkyl, halo-C1-C8-alkyl, hydroxy-C1-C8-alkyl, hydroxyl, C1-C8-alkoxy, C1-C8-alkoxy-C1-C8-alkyl, amino, N—C1-C8-alkylamino, N,N-di-C1-C8-alkyl-amino, C1-C8-alkyl-carbonyl, halo-C1-C8-alkyl-carbonyl, hydroxy-C1-C8-alkyl-carbonyl or C1-C8-alkoxy-C1-C8-alkyl-carbonyl;
• wherein ‘heterocyclyl’ can be attached at a heteroatom or a carbon atom and where the N and/or S heteroatoms can also optionally be oxidized to various oxidation states,
• wherein ‘heteroaryl’ is a 3 to 7 membered fully unsaturated monocyclic ring system containing 1 to 3 heteroatoms selected from N, O or S, or pyrazolo[1,5-a]pyrimidine or imidazo[2,1-b]thiazole, each of which is unsubstituted or substituted by 1-5 substituents selected from halogen, C1-C8-alkyl, halo-C1-C8-alkyl, hydroxy-C1-C8-alkyl, hydroxyl, C1-C8-alkoxy, C1-C8-alkoxy-C1-C8-alkyl, amino, N—C1-C8-alkyl-amino, N,N-di-C1-C8-alkyl-amino, C1-C8-alkyl-carbonyl, halo-C1-C8-alkyl-carbonyl, hydroxy-C1-C8-alkyl-carbonyl or C1-C8-alkoxy-C1-C8-alkyl-carbonyl;
• wherein ‘heteroaryl’ can be attached at a heteroatom or a carbon atom and where the N and/or S heteroatoms can also optionally be oxidized to various oxidation states;
• R6 is selected from hydrogen, halogen, C1-C4-alkyl, halo-C1-C4-alkyl, C1-C4alkoxy, C1-C4-alkyl-sulfonyl, C1-C4alkyl-sulfinyl, C1-C4alkyl-sulfanyl, halo-C1-C4-alkoxy, C1-C4-alkoxy-C1-C4-alkyl, amino, N—C1-C8-alkyl-amino, N,N-di-C1-C8-alkyl-amino;
• R7 is selected from hydrogen, halogen, cyano, nitro, C1-C4-alkyl, halo-C1-C4-alkyl, C1-C4-alkoxy, N(R8)2-sulfonyl, C1-C4-alkyl-sulfonyl, C1-C4-alkyl-sulfonyl-amino, C1-C8-alkoxy-C1-C8-alkyl, amino, N—C1-C8-alkyl-amino, or N,N-di-C1-C8-alkyl-amino;
• or R6 and R7, together are CH═CH—CH═CH,
• wherein R8 is independently selected from hydrogen, C1-C4-alkyl, C1-C4-alkoxy or two R8 together with the nitrogen they are attached to form a 4 to 7 membered heterocyclic ring containing 1-2 heteroatoms selected from N, O, S, which is unsubstituted or substituted by 1-3 substituents selected from C1-C4-alkyl;
• R5 is independently selected from H, D, F or C1-C2-alkyl;
• R30 is independently selected from H, D or F.