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US 9,539,257 B2Granted
Method of treating cancer
AssigneeNovartis AG
InventorsNan Bing, Linda Perry Briley, Laura R. Budde, Charles J. Cox, Colin F. Spraggs
Life of this patent
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Abstract
Methods are provided of treating a human for cancer comprising administering at least one dose of lapatinib, or a pharmaceutically acceptable salt or composition thereof, to a patient, wherein said patient does not have one or more allelic polymorphisms selected from the group of: HLA-DQA1*0201, HLA-DQB1*0202, and HLADRB1*0701. Patients may also be free of genotypes in TNXB; rs12153855 and/or rs17207923.
Claims6
A method of treating a human for breast cancer comprising:
- (a) obtaining a biological sample from said human;
- (b) detecting whether an allelic polymorphism at HLA-DQA1*0201 is present in said biological sample;
- (c) determining that said human does not have an allelic polymorphism at HLA-DQA1*0201 based on detecting the absence of said allelic polymorphism in step (b);
- and
- (d) administering at least one dose of lapatinib or a pharmaceutically acceptable salt or composition thereof to said human, thereby treating the human for breast cancer.
2 more elements
Dependencies are inferred from the claim text.