Compositions and methods for treatment of neurodegenerative disease
OwnerDonald Jeffrey Zack, Thomas Bannister +3inventors
InventorsDonald Jeffrey Zack, Thomas Bannister, Tomas Vojkovsky, Zhiyong Yang, Cynthia Berlinicke
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Abstract
Compounds, compositions, kits and methods for treating conditions related to neurodegeneration or ocular disease, are disclosed.
Claims25
A method of therapeutically treating macular degeneration in a subject in need thereof, the method comprising administering to a subject in need thereof an effective amount of a compound of formula (I) or formula (II):
- wherein:
- X is S(O);
- R1 is substituted or unsubstituted C1-C6 alkyl, C3-C6 cycloalkyl or allyl;
- R2 is H or substituted or unsubstituted C1-C6 alkyl, C3-C6 cycloalkyl or allyl;
- R3 is selected, independently for each occurrence, from the group consisting of substituted or unsubstituted C1-C6 alkyl, C3-C6 cycloalkyl, allyl, substituted or unsubstituted C1-C6 alkoxy, aryl, cyano, halogen, hydroxy, oxo, amino, or —C(O)—Ra, in which Ra is substituted or unsubstituted C1-C6 alkyl, C3-C6 cycloalkyl, allyl, substituted or unsubstituted C1-C6 alkoxy, aryl, or amino;
- R4 is H, substituted or unsubstituted C1-C6 alkyl, C3-C6 cycloalkyl or allyl;
- R7 is H or substituted or unsubstituted C1-C6 alkyl, C3-C6 cycloalkyl or allyl;
- R8 and R9 are each independently H, substituted or unsubstituted C1-C6 alkyl, C3-C6 cycloalkyl or allyl;
- or R8 and R9, together with the nitrogen atom to which they are attached, form a 4-10-membered heterocyclic ring;
- and
- n is 0 to 4;
- or a pharmaceutically acceptable salt or solvate thereof.
A kit comprising a compound of formula (I) or formula (II), or a pharmaceutically acceptable salt or solvate thereof, in unit dosage form, together with instructions for using the compound, or a pharmaceutically acceptable salt or solvate thereof, for therapeutically treating macular degeneration, wherein the compound of formula (I) or formula (II) comprises:
- wherein:
- X is S(O);
- R1 is substituted or unsubstituted C1-C6 alkyl, C3-C6 cycloalkyl or allyl;
- R2 is H or substituted or unsubstituted C1-C6 alkyl, C3-C6 cycloalkyl or allyl;
- R3 is selected, independently for each occurrence, from the group consisting of substituted or unsubstituted C1-C6 alkyl, C3-C6 cycloalkyl, allyl, substituted or unsubstituted C1-C6 alkoxy, aryl, cyano, halogen, hydroxy, oxo, amino, or —C(O)—Ra, in which Ra is substituted or unsubstituted C1-C6 alkyl, C3-C6 cycloalkyl, allyl, substituted or unsubstituted C1-C6 alkoxy, aryl, or amino;
- R4 is H, substituted or unsubstituted C1-C6 alkyl, C3-C6 cycloalkyl or allyl;
- R7 is H or substituted or unsubstituted C1-C6 alkyl, C3-C6 cycloalkyl or allyl;
- R8 and R9 are each independently H, substituted or unsubstituted C1-C6 alkyl, C3-C6 cycloalkyl or allyl;
- or R8 and R9, together with the nitrogen atom to which they are attached, form a 4-10-membered heterocyclic ring;
- and
- n is 0 to 4.
Dependencies are inferred from the claim text.