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AssigneeThe Texas A&M University System
InventorsJames Sacchettini, Niam Zhou, Dwight Baker, Steven A. Maxwell, Deeann Wallis
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The disclosure provides rifamycin and rifamycin derivative compositions, including rifabutin and rifabutin derivative compositions able to cause drug-sensitization in a cancer cell or inhibition of a cancer cell. The disclosure also provides methods of administering such compositions to cancer cells to sensitize them to drugs, such as chemotherapeutics, or directly inhibit them. The disclosure also provides methods of administering such compositions to increase reactive oxygen species (ROS), particularly superoxides, in cancer cells. The disclosure further provides methods of determining whether a cancer will respond to chemotherapeutics and whether to administer rifamycin or a rifamycin derivative based on ROS levels in cancer cells of a patient.
A method of sensitizing a cancer cell to a drug comprising administering rifamycin or rifabutin to the cancer cell in an amount and for a time sufficient to sensitize the cancer cell to the drug.
A method of inhibiting a cancer cell with a drug comprising:
A method of increasing susceptibility of a cancer cell to a drug comprising:
Dependencies are inferred from the claim text.