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AssigneeKorea Ocean Research and Development Institute
InventorsJoung Han Yim, Il Chan Kim, Sung Gu Lee, Doc Kyu Kim, Se Jong Han, Hyoung Seok Lee, Sung Jin Kim, Tai Kyoung Kim, Pil-Sung Kang, Heeyong Park, Ha Ju Park, Suhkneung Pyo, Babita Paudel-Bhattarai
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The present invention relates to the novel use (anti-inflammatory activity) of Ramalin isolated from the Antarctic lichen Ramalina terebrata, and more specifically to a pharmaceutical composition containing Ramalin as an active ingredient. Ramalin of the invention is a compound derived from natural material, has no toxicity or side effects, and inhibits the expression of inducible nitric oxide synthase (iNOS) in the transcription stage to significantly inhibit the production of nitric oxide (NO) that is a key mediator of inflammatory responses. In addition, it inhibits the activation of the inflammatory mediator NF-κB, inhibits p38 MAPK, ERK1/2 and JNK signaling pathways, and inhibits the expression of the LPS receptor TLR4, suggesting that Ramalin has an excellent anti-inflammatory effect. Thus, the composition containing Ramalin can be effectively used to fundamentally treat or prevent inflammatory diseases or immune diseases and to relieve or alleviate the symptoms of the diseases.
A method of reducing inflammation in a subject comprising administering a composition comprising Ramalin or a pharmaceutically acceptable salt thereof as an active ingredient to a subject, wherein the Ramalin has a structure of the following formula 1:
A method of inhibiting production of nitric oxide in cells of a subject comprising administering a composition comprising an isolated form of Ramalin or a pharmaceutically acceptable salt thereof as an active ingredient to the subject, wherein the Ramalin has a structure of the following formula 1:
Dependencies are inferred from the claim text.