Method of treating airway diseases with β-adrenergic inverse agonists
AssigneesEgb Advisors, LLC, Invion Limited
InventorRichard A. Bond
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Abstract
The use of β-adrenergic inverse agonists provides a new and highly efficient way of treating a number of pulmonary airway diseases, including asthma, emphysema, and chronic obstructive pulmonary diseases. In general, such a method comprises administering a therapeutically effective amount of a β-adrenergic inverse agonist to the subject to treat the pulmonary airway disease. Particularly preferred inverse agonists include nadolol and carvedilol.
Claims18
A method for treatment of pulmonary airway disease in a subject suffering from pulmonary airway disease comprising chronically administering a therapeutically effective amount of a β-adrenergic inverse agonist to the subject to treat the pulmonary airway disease by action of inverse agonism to promote long-term upregulation of the population of β-adrenergic receptors upon chronic administration of the β-adrenergic inverse agonist, wherein the β-adrenergic inverse agonist exhibits inverse agonist activity at the β2 receptor of bronchial tissue, wherein the β-adrenergic inverse agonist is selected from the group consisting of nadolol, bupranolol, butoxamine, carazolol, ICI-118,551, levobunolol, metoprolol, and timolol, and wherein such chronic administration requires increasing dosages over time.
Dependencies are inferred from the claim text.