Methods for treating suicidal ideation
AssigneesIcahn School of Medicine at Mount Sinai, Yale University, The United States of America, as represented by the Secretary, Department of Health and Human Services
InventorsDennis S. Charney, Sanjay J. Mathew, Husseini K. Manji, Carlos A. Zarate, John H. Krystal
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Abstract
Methods and compositions for the treatment of treatment-resistant depression are described. More specifically, the invention demonstrates that intranasal administration of ketamine is effective to ameliorate the symptoms of depression in a patient who has not responded to an adequate trial of one antidepressant in the current episode and has recurrent or chronic depressive symptoms (>2 years).
Claims9
A method of treating recurrent thoughts of death, suicidal ideation or suicidal attempts, consisting of intranasally administering to a patient who suffers from at least one of said recurrent thoughts of death, suicidal ideation or suicidal attempts a composition consisting of ketamine at a dosage sufficient to alleviate said recurrent thoughts of death, suicidal ideation or suicidal attempts and at least one pharmaceutically acceptable excipient.
A method of treating recurrent thoughts of death, suicidal ideation or suicidal attempts which consists of intranasally administering to a patient who suffers from at least one of said recurrent thoughts of death, suicidal ideation or suicidal attempts a composition containing a first component consisting of ketamine at a dosage sufficient to alleviate said recurrent thoughts of death, suicidal ideation or suicidal attempts and a second component comprising at least one pharmaceutically acceptable excipient.
Dependencies are inferred from the claim text.