Nanoparticle compositions
AssigneeAllertein Therapeutics, LLC
InventorsHoward Sosin, Michael Caplan, Tarek Fahmy
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Abstract
The present invention provides, among other things, nanoparticle compositions including a plurality of nanoparticles, each of which is comprised of a biodegradable or biocompatible polymer arranged in a nanoparticle structure defining an internal lumen and an external surface and one or more of a preparation of hydrophilic cellular components and a preparation of hydrophobic cellular components. In some embodiments, the preparation of hydrophilic cellular components is encapsulated within the internal lumen and the preparation of hydrophobic cellular components is associated with the external surface. Various methods of making and using disclosed nanoparticle compositions are also provided.
Claims20
A nanoparticle composition comprising:
- a plurality of nanoparticles, each of which is comprised of a biodegradable or biocompatible polymer arranged in a nanoparticle structure whose external surface is coated with a preparation comprising a crude hydrophobic bacterial extract and a hydrophilic antigen encapsulated by the nanoparticle structure so that, when the nanoparticle composition is administered to a subject, the antigen is hidden from immune system components.
A method comprising administering to a human subject in need thereof a nanoparticle composition comprising:
- a plurality of nanoparticles, each of which is comprised of a biodegradable or biocompatible polymer arranged in a nanoparticle structure whose external surface is coated with a preparation comprising a crude hydrophobic bacterial extract;
- and
- a hydrophilic antigen encapsulated by the nanoparticle structure so that, when the nanoparticle composition is administered to the human subject, the antigen is hidden from immune system components.
A method of forming a nanoparticle composition comprising:
- providing a hydrophilic preparation comprising an antigen;
- providing a biodegradable or biocompatible polymer;
- associating the hydrophilic preparation with the biodegradable or biocompatible polymer so that nanoparticles comprising the polymer and the preparation are formed;
- and
- coating the nanoparticles with a crude hydrophobic bacterial extract.
Dependencies are inferred from the claim text.