Apparatus and methods for ocular injection

An apparatus, comprising:

• a housing configured to receive a portion of a medicament container;
• a hub coupled to the housing, the hub defining a passageway configured to receive a puncture member therethrough, the hub having a distal end surface, the distal end surface of the hub configured to contact a target surface of a target tissue when a substance is conveyed through the puncture member;
• and
• an actuation rod at least partially disposed within the medicament container,
• the puncture member fixedly coupled to the hub such that the hub moves with the puncture member when the puncture member is moved relative to the target surface
• the medicament container, the actuation rod, and the puncture member collectively configured such that (1) a distal end portion of the actuation rod moves within and relative to the medicament container in response to a force on the actuation rod when a distal end portion of the puncture member is disposed within a first region of the target tissue, and (2) movement of the distal end portion of the actuation rod within and relative to the medicament container in response to the force on the actuation rod is limited when the distal end portion of the puncture member is disposed within a second region of the target tissue, the force having a magnitude less than a threshold value.

An apparatus, comprising:

• a housing configured to receive a portion of a medicament container;
• a hub, the hub coupled to the housing and defining a passageway configured to receive a puncture member therethrough, the hub having a distal end surface, the distal end surface of the hub configured to contact a target surface of a target tissue when a substance is conveyed through the puncture member;
• and
• an actuation rod, the actuation rod configured to be coupled to the medicament container, the actuation rod and the puncture member collectively configured such that (1) a distal end portion of the actuation rod moves within the medicament container in response to a force on the actuation rod when a distal end portion of the puncture member is disposed within a first region of the target tissue and the actuation rod is coupled to the medicament container, and (2) movement of the distal end portion of the actuation rod within the medicament container in response to the force on the actuation rod is limited when the distal end portion of the puncture member is disposed within a second region of the target tissue and the actuation rod is coupled to the medicament container, the force having a magnitude less than a threshold value.