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US 9,538,926 B2Granted
Speckle contrast optical tomography
AssigneesFundació Institut De CièNcies FotòNiques, Washington University
InventorsTurgut Durduran, Claudia Valdes, Anna Kristoffersen, Hari M. Varma, Joseph Culver
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Abstract
Speckle contrast optical tomography system provided with at least one point source and multiple detectors, means for providing different source positions, the point source having a coherence length of at least the source position-detector distance and means for arranging the source position-detector pairs over a sample to be inspected, the system being further provided with means for measuring the speckle contrast; the speckle contrast system of the invention thus capable of obtaining 3D images.
Claims6
A speckle contrast optical tomography system comprising:
- a plurality of point sources each adapted to generate light, each of the plurality of point sources located at a respective first location over a sample to be examined;
- a plurality of detectors located at respective second locations relative to the sample;
- and
- wherein the plurality of point sources and the plurality of detectors are arranged over a tissue volume of the sample in an arrangement that defines a plurality of source position-detector pairs adapted to examine the tissue volume;
- the speckle contrast optical tomography system further comprising:
- a processing device adapted to:
- determine a speckle contrast between each of the plurality of source position-detector pairs, after light transverses the tissue volume, both in the absence of flow and in the presence of flow, thereby generating speckle contrast data;
- correct the speckle contrast data for shot-noise error and intensity gradients;
- and
- construct a speckle contrast forward model by performing the following steps:
- computing a field autocorrelation for the plurality of source positions and the plurality of detectors;
- computing the speckle contrast for the plurality of source positions and the plurality of detectors;
- computing a difference value defining a relationship between the speckle contrast corrected for shot noise and intensity gradients and a baseline speckle contrast measurement value;
- and
- determining a linear system of equations having a solution that provides a flow contrast, based at least in part on the difference value.
12 more elements
A speckle contrast optical tomography system comprising:
- a laser point source adapted to generate light;
- a plurality of detectors arranged over a sample to be examined;
- and
- a plurality of galvanometric mirrors adapted to provide a plurality of source positions for scanning the source over the sample;
- wherein the plurality of galvanometric mirrors and the plurality of detectors are arranged over a tissue volume of the sample in an arrangement that defines a plurality of source position-detector pairs adapted to examine the tissue volume;
- wherein the laser point source has a coherence length of at least a source position-detector distance;
- the speckle contrast optical tomography system further comprising:
- a processing device adapted to:
- determine a speckle contrast between each of the plurality of source position-detector pairs, after light transverses the tissue volume, both in the absence of flow and in the presence of flow, thereby generating speckle contrast data;
- correct the speckle contrast data for shot-noise error and intensity gradients;
- and
- construct a speckle contrast forward model by performing the following steps:
- computing a field autocorrelation for the plurality of source positions and the plurality of detectors;
- computing the speckle contrast for the plurality of source positions and the plurality of detectors;
- computing a difference value defining a relationship between the speckle contrast corrected for shot noise and intensity gradients and a baseline speckle contrast measurement value;
- and
- determining a linear system of equations having a solution that provides a flow contrast, based at least in part on the difference value.
14 more elements
A speckle contrast optical tomography system comprising:
- a laser adapted to generate light;
- a plurality of detectors arranged over a volume of a sample to be examined;
- a plurality of optical fibers adapted to guide the light from the laser to a plurality of source positions;
- wherein the laser has a coherence length of at least a source position-detector distance;
- wherein the plurality of detectors and the plurality of source positions are arranged over a tissue volume of the sample in an arrangement that defines a plurality of source position-detector pairs adapted to examine the tissue volume;
- the speckle contrast optical tomography system further including:
- a processing device adapted to:
- measure a speckle contrast for each of the plurality of source position-detector pairs, after the light transverses the tissue volume, both in the absence of flow and in the presence of flow, to generate speckle contrast data;
- correct the speckle contrast data for shot-noise error and intensity gradients;
- and
- construct a speckle contrast forward model for the speckle contrast optical tomography system by performing the following steps:
- computing a field autocorrelation for the plurality of source positions and the plurality of detectors;
- computing the speckle contrast for the plurality of source positions and the plurality of detectors;
- computing a difference value defining a relationship between the speckle contrast corrected for shot noise and intensity gradients and a baseline speckle contrast measurement value;
- and
- determining a linear system of equations having a solution that provides a flow contrast, based at least in part on the difference value.
13 more elements
Dependencies are inferred from the claim text.