Oral nicotine-substituted cytisine atomized liquid and its preparation method

A method of preparing oral nicotine-substituted cytisine atomized liquid comprising the following components in mass percentage per 1 L of the oral nicotine-substituted cytisine atomized liquid:

• 0.1-10% of tobacco, 0.3-15% of cocoa extract, 0.1-0.9% of cytisine, 0.1-0.5% of Polysorbate 80 and 75-90% of primer, wherein the primer is propylene glycol, polyethylene glycol, glycerol or mixtures thereof;
• the method comprises the following steps:
• (1) weighing the tobacco according to said mass percentage;
• putting the tobacco into an extraction tank;
• (2) measuring the Polysorbate 80 according to said mass percentage and the primer according to said mass percentage respectively, adding the Polysorbate 80 into the primer, stirring and mixing the Polysorbate 80 and the primer for 20-40 minutes to obtain a mixture, adding the mixture into the extraction tank and soaking the tobacco with the mixture for 30-90 minutes, then heating up the tobacco to a temperature of 40-60° C. by introducing steam in the extraction tank, extracting the tobacco for 3-6 hours to obtain an extract while maintaining the temperature during extraction, filtering the extract to obtain a filtrate;
• (3) stirring and mixing the cocoa extract according to said mass percentage with the filtrate for 30-60 minutes;
• (4) adding the cytisine according to said mass percentage into the filtrate;
• and
• (5) adding the primer according to said mass percentage to the filtrate to reach an intended total volume of the oral nicotine-substituted cytisine atomized liquid, stirring and mixing the filtrate for 20-40 minutes until the filtrate is evenly mixed, thereby obtaining the oral nicotine-substituted cytisine atomized liquid.