Human lung stem cells and uses thereof
AssigneeAal Scientifics, Inc.
InventorsPiero Anversa, Annarosa Leri
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Abstract
Embodiments of the invention relate to human stem cells and their therapeutic use in the treatment and/or prevention of lung diseases. Provided herein are compositions comprising c-kit positive human lung stem cells and methods of preparing and using c-kit positive human lung stem cells for the treatment and/or prevention of lung diseases.
Claims8
A method for ameliorating a symptom, preventing and/or slowing the progression of a respiratory disease resulting in pathological damage to lung or airway architecture and/or alveolar damage or its symptoms in a human subject in need thereof, comprising administering a pharmaceutical composition comprising:
- (a) an isolated population of cells from a human lung tissue, the isolated population of cells is enriched for c-kit positive lung stem cells and is negative for the markers:
- CD2, CD3, CD6, CD8, CD14, CD16, CD19, CD20, CD24, CD29, CD34, CD44, CD45, CD49d, CD49e, CD66b, CD90, CD105, CD133, glycophorin A, TTF1, p63, pan-cytokeratin, cytokeratin 5, CC10, aquaporin-5, SPC, Est1, vWF1, GATA 6, and alpha-SMA;
- and
- (b) a pharmaceutically acceptable carrier to the subject to ameliorate a symptom, prevent and/or slow the progression of the respiratory disease or its symptoms, wherein the composition comprises at least 102 cells.
Dependencies are inferred from the claim text.