Culture of pluripotent autologous stem cells from oral mucosa
AssigneeRamot at Tel-Aviv University Ltd.
InventorSandu Pitaru
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Abstract
The present invention provides a new readily accessible source of adult somatic stem cells from the gastrointestinal tract in general and oral mucosa in particular, methods for isolating pluripotent stem cells from oral mucosa, cells derived therefrom and uses thereof.
Claims8
A culture comprising pluripotent stem cells that originated in the lamina propria of the oral mucosa, in an in vitro culture medium that ensures growth in vitro without production of differentiated progeny cells at the expense of the pluripotent stem cells, wherein said stem cells each display all of the markers Nestin, p75, Sox2, Oct4 and Nanog.
A pluripotent stem cell that originated in the lamina propria of the oral mucosa which displays all of the markers Nestin, p75, Sox2, Oct4 and Nanog, and which stem cell further includes a foreign gene that has been inserted into the stem cell by genetic manipulation.
Dependencies are inferred from the claim text.