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US 9,534,048 B2Granted
Antibodies to TTR and methods of use
AssigneeUniversity Health Network
InventorsAvijit Chakrabartty, Rishi Rakhit, Anita Antoinette Bugyei-Twum
Life of this patent
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Abstract
The disclosure pertains to antibodies and binding fragments thereof that specifically binds all or part of EHAEVVFTA. Also provided are isolated peptides, isolated nucleic acids, immunogens, compositions, immunoassays and kits and method of using said reagents to detect misfolded TTR.
Claims23
A conformation specific antibody or binding fragment thereof that specifically binds all of EHAEVVFTA (SEQ ID NO:
- 1), wherein the antibody or binding fragment thereof is capable of binding to TTR amyloid fibrils as found in situ in a biological sample obtained from a subject.
A conformation specific antibody or binding fragment thereof that specifically binds all of EHAEVVFTA (SEQ ID NO:
- 1), wherein the antibody or binding fragment thereof selectively binds a misfolded TTR conformation at least 2 fold more efficiently than it binds natively folded tetramer TTR.
Dependencies are inferred from the claim text.