Synergistic bacterial compositions and methods of production and use thereof
AssigneeSeres Therapeutics, Inc.
InventorsMatthew R. Henn, Geoffrey von Maltzahn, Anthony Mario D'Onofrio, Kevin Daniel Litcofsky, David Arthur Berry, David N. Cook, Noubar B. Afeyan, John Grant Aunins
Life of this patent
Estimating the term…
Abstract
Provided are therapeutic compositions containing Ecobiotic™ populations for prevention, treatment and reduction of symptoms associated with a dysbiosis of a mammalian subject such as a human.
Claims11
A method of treating an occurrence or a recurrence of a Clostridium difficile infection, comprising administering to a human subject in need thereof an effective amount of a therapeutic composition comprising a first purified bacterial population consisting of a first bacteria comprising a 16S rDNA sequence at least about 97% identical to a 16S rDNA sequence present in a reference Collinsella aerofaciens OTU, and a second purified bacterial population consisting of a second bacteria comprising a 16S rDNA sequence at least about 97% identical to a 16S rDNA sequence present in a reference bacterium of the family Clostridiaceae listed in Table 1, wherein a synergistic combination of the first bacteria and the second bacteria is cytotoxic or cytostatic to a Clostridium difficile.
Dependencies are inferred from the claim text.