Intraperitoneally-administered nanocarriers that release their therapeutic load based on the inflammatory environment of cancers
AssigneeStc.Unm
InventorReema Zeineldin
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Abstract
In one embodiment, the invention provides a new design of nanocarrier compositions that release their therapeutic load specifically at intraperitoneal cancers' site. These nanocarriers are administered intraperitoneally and comprise a plurality of porous nanoparticulates that (a) are loaded with one or more pharmaceutically-active agents alone or in combination with imaging agents thus providing a theranostic value and (b) that are encapsulated by and that support a lipid bilayer which is disrupted upon contact with a reactive oxygen species generated within the environment of the cancer. In other embodiments, the invention provides methods of treatment and pharmaceutical compositions comprising nanocarriers as described herein.
Claims15
A method of treating a subject who suffers from a cancer, the method comprising intraperitoneally administering to the subject a pharmaceutically effective amount of a nanocarrier composition, comprising a plurality of porous nanoparticulates that are loaded with one or more pharmaceutically active anticancer agents and are encapsulated by and support a lipid bilayer which is disrupted upon contact with a reactive oxygen species, wherein the lipid bilayer comprises 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC).
A method of treating a subject suffering from peritoneal cancer, the method comprising intraperitoneally administering to the subject a pharmaceutically effective amount of a nanocarrier composition, said nanocarrier composition comprising a plurality of porous silica nanoparticulates that:
- (a) are loaded with one or more pharmaceutically-active agents selected from the group consisting of doxorubicin, melphalan, bevacizumab, dactinomycin, cyclophosphamide, amifostine, etoposide, gemcitabine, altretamine, topotecan, a taxane or a platinum based chemotherapeutic agent, and
- (b) that are encapsulated by and that support a lipid bilayer comprising 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) to form a nanocarrier;
- wherein subsequent to administration, the lipid bilayer is disrupted in vivo upon contact with a reactive oxygen species (ROS) selected from the group consisting of ozone (O3), hydrogen peroxide, hypochlorite ion, hydroxyl radical, superoxide anion (O2−), and peroxynitrite.
Dependencies are inferred from the claim text.