Recombinant polynucleotide and a transgenic Flammulina velutipes carrying the same
AssigneeMycomagic Biotechnology Co., Ltd.
InventorYing-Tzu Lyu
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Abstract
The invention provides a recombinant polynucleotide comprising a truncated glyceraldehyde-3-phosphate dehydrogenase (gpd) promoter and a modified HBV S protein gene and a transgenic Flammulina velutipes carrying the recombinant polynucleotide. The invention surprisingly found that after administering the transgenic Flammulina velutipes to a subject, the subject can successfully generate an antibody against HBV. Therefore, the transgenic Flammulina velutipes can be used as a vaccine against HBV.
Claims16
A recombinant polynucleotide, comprising a glyceraldehyde-3-phosphate dehydrogenase (gpd) promoter comprising the nucleotide sequence set forth in SEQ ID NO:
- 1 and a modified HBV S protein gene comprising the nucleotide sequence set forth in SEQ ID NO:
- 2.
A transgenic F. velutipes, which is deposited with Deutsche Sammlung von Mikroorganismen and Zellkulturen (DSMZ) under deposit number DSM 27789.
Dependencies are inferred from the claim text.