Steroid analogues for neuroprotection
AssigneeEmory University
InventorsChristopher Macnevin, Donald G. Stein, Dennis C. Liotta, Iqbal Sayeed, David B. Guthrie, Mark A. Lockwood, Michael G. Natchus
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Abstract
Provided are steroid analogues functionalized with polar substituents at the C3 and/or C20 positions of the steroid ring system that exhibit improved water solubility. Also provided are pharmaceutical compositions comprising the steroid analogues and methods using the novel steroid analogues for the treatment and prevention of neurodegeneration in a patient following injury to the central nervous system.
Claims3
A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a steroid compound of the Formula VII:
- or a pharmaceutically acceptable salt-thereof, wherein:
- R1 R2, R5 and R6 are independently hydrogen, alkyl, halogen, hydroxyl cycloalkyl, cycloalkenyl, alkenyl, alkynyl, aryl, alkylaryl, arylalkyl, heterocyclic, heteroaryl, amino, thiol, alkoxy, sulfide, nitro, cyano, azide, sulfonyl, acyl, carboxyl, an ester, an amide, carbamate, carbonate, an amino acid residue or a carbohydrate;
- R3 —OR11;
- R11 is —C(O)R′, where R′ is alkyl, or the residue of an amino acid;
- and
- the dotted line indicates the presence of either a single bond or a double bond, wherein the valences of a single bond are completed by hydrogens.
Dependencies are inferred from the claim text.