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AssigneeVitae Pharmaceutical, Inc
InventorsYuri Bukhtiyarov, Salvacion Cacatian, Lawrence Wayne Dillard, Cornelia Dorner-Ciossek, Klaus Fuchs, Lanqi Jia, Deepak S. Lala, Angel Morales-Ramos, Jonathan Reeves, Suresh B. Singh, Shankar Venkatraman, Zhenrong Xu, Jing Yuan, Yi Zhao, Yajun Zheng, Georg Rast
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The present invention relates to spirocyclic acylguanidines and their use as inhibitors of theβ-secretase enzyme (BACE1) activity, pharmaceutical compositions containing the same, and methods of using the same as therapeutic agents in the treatment of neurodegenerative disorders, disorders characterized by cognitive decline, cognitive impairment, dementia and diseases characterized by production of β-amyloid aggregates.
A method of treating a BACE1 mediated disorder or disease in a subject, wherein the disorder or disease is selected from the group consisting of Down's Syndrome, HCHWA-D, cognitive impairment and cognitive decline, comprising administering to a subject an effective amount of a compound selected from:
Dependencies are inferred from the claim text.