Chemical engineering processes and apparatus for the synthesis of compounds
AssigneeFull Spectrum Laboratories Limited
InventorsRobert Winnicki, Marc Donsky
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Abstract
The present invention provides methods for producing cannabinoids and cannabinoid analogs as well as a system for producing these compounds. The inventive method is directed to contacting a compound according to Formula I or Formula II with a cannabinoid synthase. Also described is a system for producing cannabinoids and cannabinoid analogs by contacting a THCA synthase with a cannabinoid precursor and modifying at least one property of the reaction mixture to influence the quantity formed of a first cannabinoid relative to the quantity formed of a second cannabinoid.
Claims23
An in vitro method for producing
- (a) tetrahydrocannabinolic acid (THCA) and cannabichromenic acid (CBCA) in different ratios or
- (b) cannabidiolic acid (CBDA) and cannabichromenic acid (CBCA) in different ratios comprising the steps of:
- reacting cannabigerolic acid (CBGA) with a cannabinoid synthase in a reaction mixture;
- modifying one or more properties of the reaction mixture to produce
- (i) tetrahydrocannabinolic acid (THCA) and cannabichromenic acid (CBCA) when the cannabinoid synthase is tetrahydrocannabinolic acid synthase (THCA synthase);
- or
- (ii) cannabidiolic acid (CBDA) and cannabichromenic acid (CBCA) when the cannabinoid synthase is cannabidiolic acid synthase (CBDA synthase);
- and
- recovering the tetrahydrocannabinolic acid (THCA) and cannabichromenic acid (CBCA) or tetrahydrocannabinolic acid (THCA) and cannabichromenic acid (CBCA) so produced, wherein the different ratios are determined by a pH of the reaction mixture less than 8.0, which allows for the different ratios.
An ex vivo method for producing tetrahydrocannabinolic acid (THCA) and cannabichromenic acid (CBCA) in different ratios comprising the steps of:
- reacting cannabigerolic acid (CBGA) with tetrahydrocannabinolic acid synthase (THCA synthase) in a reaction mixture;
- modifying one or more properties of the reaction mixture to produce tetrahydrocannabinolic acid (THCA) and cannabichromenic acid (CBCA) in different ratios;
- and
- recovering the tetrahydrocannabinolic acid (THCA) and cannabichromenic acid (CBCA) so produced, wherein the different ratios are determined by a pH of the reaction mixture less than 8.0 which allows for the different ratios.
An ex vivo method for producing cannabidiolic acid (CBDA) and cannabichromenic acid (CBCA) in different ratios comprising the steps of:
- reacting cannabigerolic acid (CBGA) with cannabidiolic acid synthase (CBDA synthase) in a reaction mixture;
- modifying one or more properties of the reaction mixture to produce cannabidiolic acid (CBDA) and cannabichromenic acid (CBCA) in different ratios;
- and
- recovering the cannabidiolic acid (CBDA) and cannabichromenic acid (CBCA) so produced, wherein the different ratios are determined by a pH of the reaction mixture less than 8.0, which allows for the different ratios.
Dependencies are inferred from the claim text.