PI polyamide
AssigneeNihon University
InventorsDaisuke Obinata, Satoru Takahashi, Kyoko Fujiwara, Satoshi Inoue, Kenichi Takayama
Life of this patent
Estimating the term…
Abstract
To provide a safe and stable medicine useful for prevention and treatment of prostate cancer. A novel PI polyamide is acquired that recognizes and binds to a specific base sequence of an Oct1 gene binding sequence present in a transcriptional regulatory region (AR response region) of an ACSL3 gene and regulating the transcription activity of AR. This leads to the provision of an ACSL3 gene expression inhibitor and a preventive and/or therapeutic agent of prostate cancer containing the PI polyamide as an active ingredient.
Claims3
A pyrrole-imidazole polyamide binding to the whole or a part of a base sequence comprising SEQ ID NO:1, the pyrrole-imidazole polyamide being represented by any of the following Formulas 1 to 3:
An ACSL3 gene expression inhibitor containing a pyrrole-imidazole polyamide represented by any of the following Formulas 1 to 3:
- as an active ingredient.
A preventive or therapeutic agent of prostate cancer containing the pyrrole-imidazole polyamide represented by any of the following Formulas 1 to 3:
- as an active ingredient.
Dependencies are inferred from the claim text.