Hypoallergenic chimeric proteins belonging to the lipid transfer family of Parietaria judaica for use in the treatment of allergies
AssigneeBial Industrial Farmaceutica, S.A.
InventorsJuan Andres Asturias, Alberto Martinez Garate, Roberto Gonzales Rioja
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Abstract
The present invention relates to recombinant DNA molecules which encode chimeric polypeptides of differing allergens of Parietaria judaica which can be used for the prevention and treatment of allergies, in particular pollen allergies. Specifically, chimeric polypeptides composed of fragments of the allergens Par j 1 and Par j 2 having hypoallergenic characteristics are described. Methods for producing these recombinant polypeptides in heterologous expression systems are also described. Efficient methods of purifying the chimeric proteins are also described.
Claims77
A polynucleotide comprising a nucleotide sequence encoding a chimeric protein, wherein the chimeric protein consists of an amino acid sequence with homology of at least 70% of SEQ ID No.:4.
Dependencies are inferred from the claim text.