# US 9,518,083 B2 · Gadd45beta targeting agents

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- Number: US 9,518,083 B2
- Document ID: US9518083B2
- Status: Granted
- Kind: B2
- Application number: 14/618,613
- Filed: 2015-02-10
- Published: 2015-12-24
- Granted: 2016-12-13
- Earliest claimed: 2009-10-22
- Assignees: Imperial Innovations Limited
- Applicants: Imperial Innovations Limited
- Inventors: Guido Franzoso; Albert Andrzej Jaxa-Chamiec; Caroline Minli Rachel Low; Simona Maria Monti; Menotti Ruvo; Laura Tornatore; Catherine Jane Tralau-Stewart
- Web page: https://patentgrep.com/patent/US9518083B2

## CPC

- C07K 5/08: Tripeptides
- A61P 35/00: Antineoplastic agents
- C07K 5/06078: {and aromatic or cycloaliphatic}
- C07K 5/06104: {with the first amino acid being acidic}
- C07K 5/06113: {Asp- or Asn-amino acid}
- C07K 5/0812: {and aromatic or cycloaliphatic}
- C07K 5/1016: {and aromatic or cycloaliphatic}
- A61K 38/00: Medicinal preparations containing peptides (peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00)
- C07K: PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

Compounds based around tetrapeptide, tripeptide and dipeptide moeties and corresponding peptiod moeties. Related methods and pharmaceutical compositions for use in treatment of cancer, inflammatory diseases, and other disorders.

## Claims

### Claim 1

A compound according to Formula I
or a pharmaceutically acceptable salt thereof.

### Claim 2 (depends on 1)

A pharmaceutical composition comprising the compound of claim 1 and a pharmaceutically acceptable excipient.