# US 9,518,019 B2 · Process for the preparation of 4-amino-5-fluoro-3-chloro-6-(substituted)picolinates

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- Number: US 9,518,019 B2
- Document ID: US9518019B2
- Status: Granted
- Kind: B2
- Application number: 15/040,577
- Filed: 2016-02-10
- Published: 2016-06-09
- Granted: 2016-12-13
- Earliest claimed: 2012-12-13
- Assignees: Dow AgroSciences LLC
- Applicants: Dow AgroSciences LLC
- Inventors: Natalie C. Giampietro; James M. Renga
- Web page: https://patentgrep.com/patent/US9518019B2

## CPC

- C07D 213/79: Acids; Esters
- C07C 251/12: being acyclic
- C07D 213/803: Processes of preparation
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- C07C: ACYCLIC OR CARBOCYCLIC COMPOUNDS

## Abstract

4-Amino-5-fluoro-3-chloro-6-(substituted)picolinates are prepared from trifluoroacetic acid, p-methoxyaniline, a C1-C4 alkyl propiolate and a substituted methylene amine by a series of steps.

## Claims

### Claim 1

A compound of Formula E
wherein
R1 represents C1-C4 alkyl, cyclopropyl, C2-C4 alkenyl or phenyl substituted with from 1 to 4 substituents independently selected from halogen, C1-C4 alkyl, C1-C4 haloalkyl, C1-C4 alkoxy or C1-C4 haloalkoxy, and
R2 represents C1-C4 alkyl.

### Claim 2

A compound of Formula G
wherein
R1 represents C1-C4 alkyl, cyclopropyl, C2-C4 alkenyl or phenyl substituted with from 1 to 4 substituents independently selected from halogen, C1-C4 alkyl, C1-C4 haloalkyl, C1-C4 alkoxy or C1-C4 haloalkoxy, and
R2 represents C1-C4 alkyl.