# US 9,517,305 B2 · Medical fluid injector > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 9,517,305 B2 - Document ID: US9517305B2 - Status: Granted - Kind: B2 - Application number: 13/839,864 - Filed: 2013-03-15 - Published: 2014-09-18 - Granted: 2016-12-13 - Earliest claimed: 2013-03-15 - Assignees: Bayer HealthCare LLC - Applicants: Bayer Healthcare LLC - Inventors: Martin J. Uram; Michael J. Yanniello; Barry L. Tucker; David A. Mishler; Edward J. Rhinehart; Mark Trocki; Arthur E. Uber, III; Kevin P. Cowan; John A. Brosovich - Web page: https://patentgrep.com/patent/US9517305B2 ## CPC - A61M 5/1723: {using feedback of body parameters, e.g. blood sugar or pressure} - A61M 5/1452: {pressurised by means of pistons} - A61M 5/14566: {with a replaceable reservoir for receiving a piston rod of the pump} - A61M 5/16877: {Passive flow controllers; Devices for setting a flow rate (clamp-type valves A61M39/28)} - A61M 2205/18: with alarm - A61M 2205/3576: with non implanted data transmission devices, e.g. using external transmitter or receiver - A61M 2205/502: User interfaces, e.g. screens or keyboards - A61M 2205/52: with memories providing a history of measured variating parameters of apparatus or patient - A61M 2230/005: Parameter used as control input for the apparatus - A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)} ## Abstract Systems and methods for intelligently delivering fluid to a targeted tissue. The systems and methods may include directing a pump to distribute fluid to a targeted tissue and receiving one or more signals from an intracorporeal sensing system, where the one or more signals correspond to one or more sensed feedback parameters at the targeted tissue. The systems and methods may also include determining whether the one or more sensed feedback parameters are within an acceptable range. If the one or more sensed feedback parameters are not within the acceptable range, the systems and methods may include determining an adjusted velocity for the plunger necessary to adjust the pressure of the fluid in the pump so that the one or more sensed feedback parameters move within the acceptable range and directing the pump to distribute the fluid at the adjusted velocity. ## Claims ### Claim 1 A system for intelligently delivering a fluid into a targeted tissue, the system comprising: a pump configured to contain a volume of the fluid at a pressure; a processor; an intracorporeal sensing system in operable communication with the processor and adapted to sense an intravascular pressure; and a non-transitory, processor-readable storage medium in communication with the processor, wherein the non-transitory, processor-readable storage medium contains one or more programming instructions that, when executed, cause the processor to: direct the pump to distribute the fluid into the targeted tissue at an initial velocity; receive one or more signals from the intracorporeal sensing system, wherein the one or more signals correspond to one or more sensed feedback parameters at the targeted tissue, the one or more sensed feedback parameters comprising the intravascular pressure; determine whether the one or more sensed feedback parameters are within an acceptable range; if the one or more sensed feedback parameters are not within the acceptable range, determine an adjusted velocity; and direct the pump to distribute the fluid into the targeted tissue at the adjusted velocity. ### Claim 2 (depends on 1) The system of claim 1, further comprising one or more programming instructions, that, when executed, direct the processor to: receive one or more inputs, wherein the one or more inputs correspond to data that defines the acceptable range. ### Claim 3 (depends on 1) The system of claim 1, further comprising: a display in operable communication with the processor; and one or more programming instructions that, when executed, direct the processor to: direct the display to display data corresponding to the acceptable range in a user-readable format. ### Claim 4 (depends on 1) The system of claim 1, further comprising: a display in operable communication with the processor; and one or more programming instructions that, when executed, direct the processor to: direct the display to display the one or more sensed feedback parameters in a user-readable format. ### Claim 5 (depends on 1) The system of claim 1, further comprising: one or more driving devices in operable communication with the processor; and an actuation component mechanically connected to the one or more driving devices and the pump, wherein the one or more programming instructions that, when executed, cause the processor to direct the pump to distribute the fluid into the targeted tissue further comprise one or more programming instructions that, when executed, cause the processor to activate the one or more driving devices to cause the actuation component to direct the pump to distribute the fluid into the targeted tissue. ### Claim 6 (depends on 1) The system of claim 1, wherein: the pump is a syringe body; and a pressure jacket is configured to surround the syringe body and prevent the syringe body from expanding. ### Claim 7 (depends on 6) The system of claim 6, further comprising an end plug connected to a distal portion of the syringe body, wherein the end plug: is formed of a solid piece of material; comprises a bore therethrough for accurate distribution of the fluid; and is configured to prevent leakage of the fluid from the syringe body. ### Claim 8 (depends on 1) The system of claim 1, wherein the volume of the fluid is about 10 ml to about 2000 ml prior to distribution of the fluid into the targeted tissue. ### Claim 9 (depends on 1) The system of claim 1, wherein the pressure of the fluid is about 10 psi to about 2000 psi prior to distribution of the fluid into the targeted tissue. ### Claim 10 (depends on 1) The system of claim 1, wherein the intracorporeal sensing system comprises a sensor that is disposed at or near the targeted tissue. ### Claim 11 (depends on 1) The system of claim 1, wherein the one or more sensed feedback parameters further comprise one or more of an image property, a tissue stretch property, a tissue conductivity, a tissue ultrasound property, a flow rate in the targeted tissue, a fluid cell count, a fluid particle count, and a density of a measurable tracer. ### Claim 12 (depends on 1) The system of claim 1, wherein the fluid comprises one or more gene therapy ingredients. ### Claim 13 A method for automatically and intelligently delivering a fluid into a targeted tissue, the method comprising: directing, by a processor, a pump to distribute the fluid into the targeted tissue at an initial velocity; receiving, by the processor, one or more signals from an intracorporeal sensing system, wherein the one or more signals correspond to one or more sensed feedback parameters at the targeted tissue, the one or more sensed feedback parameters comprising an intravascular pressure; determining, by the processor, whether the one or more sensed feedback parameters are within an acceptable range; if the one or more sensed feedback parameters are not within the acceptable range, determining, by the processor, an adjusted velocity; and directing, by the processor, the pump to distribute the fluid into the targeted tissue at the adjusted velocity. ### Claim 14 (depends on 13) The method of claim 13, further comprising: receiving, by the processor, one or more inputs, wherein the one or more inputs correspond to data that defines the acceptable range. ### Claim 15 (depends on 13) The method of claim 13, further comprising: directing, by the processor, a display to display data corresponding to the acceptable range in a user-readable format. ### Claim 16 (depends on 13) The method of claim 13, further comprising: directing, by the processor, a display to display the one or more sensed feedback parameters in a user-readable format. ### Claim 17 (depends on 13) The method of claim 13, wherein directing the pump to distribute the fluid into the targeted tissue further comprises causing, by the processor, one or more driving devices to activate, wherein activation of the one or more driving devices causes an actuation component to direct the pump to distribute the fluid into the targeted tissue. ### Claim 18 (depends on 13) The method of claim 13, wherein directing the pump to distribute the fluid into the targeted tissue further comprises directing the pump to distribute about 10 ml to about 2000 ml of the fluid into the targeted tissue. ### Claim 19 (depends on 13) The method of claim 13, wherein directing the pump to distribute the fluid into the targeted tissue further comprises directing the pump to distribute the fluid at a pressure of about 10 psi to about 2000 psi. ### Claim 20 (depends on 13) The method of claim 13, wherein the one or more sensed feedback parameters further comprise one or more of an image property, a tissue stretch property, a tissue conductivity, a tissue ultrasound property, a flow rate in the targeted tissue, a fluid cell count, a fluid particle count, and a density of a measurable tracer. ### Claim 21 A system for intelligently delivering a fluid to a targeted tissue, the system comprising: a pump configured to contain a volume of the fluid at a pressure; a processor; an intracorporeal sensing system configured to be placed in operable communication with the processor, the intracorporeal sensing system comprising at least one sensor and at least one control for the at least one sensor, the at least one control configured to: turn the at least one sensor on, turn the at least one sensor off, specify at least one feedback parameter, direct the at least one sensor to the targeted tissue, or any combination thereof; a display in operable communication with the processor; and a non-transitory, processor-readable storage medium in communication with the processor, wherein the non-transitory, processor-readable storage medium contains one or more programming instructions that, when executed, cause the processor to: deactivate the at least one control for the at least one sensor in response to determining that the intracorporeal sensing system is in operable communication with the processor, such that the processor controls the at least one sensor; direct the pump to distribute the fluid to the targeted tissue at an initial velocity; receive one or more signals from the intracorporeal sensing system having one of the at least one sensor distributed at or near the targeted tissue, wherein the one or more signals correspond to one or more sensed feedback parameters at the targeted tissue, the one or more sensed feedback parameters comprising an intravascular pressure; receive one or more inputs, wherein the one or more inputs correspond to data that defines an acceptable range; determine whether the one or more sensed feedback parameters are within the acceptable range; direct the display to display data corresponding to the acceptable range in a user-readable format; direct the display to display the one or more sensed feedback parameters in the user-readable format; if the one or more sensed feedback parameters are not within the acceptable range, determine an adjusted velocity; and direct the pump to distribute the fluid to the targeted tissue at the adjusted velocity. ### Claim 22 (depends on 21) The system of claim 21, wherein: a predetermined total volume is programmable based on the one or more sensed feedback parameters outside the acceptable range; and the one or more programming instructions that, when executed, cause the processor to direct the pump to distribute the fluid to the targeted tissue at the adjusted velocity comprises one or more programming instructions that, when executed, cause the processor to direct the pump to distribute the fluid to the targeted tissue at the adjusted velocity based on the predetermined total volume. ### Claim 23 (depends on 1) The system of claim 1, wherein the targeted tissue comprises at least one of a vein and an artery.