# US 9,517,291 B2 · Medical devices having activated surfaces

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- Number: US 9,517,291 B2
- Document ID: US9517291B2
- Status: Granted
- Kind: B2
- Application number: 14/621,493
- Filed: 2015-02-13
- Published: 2015-06-11
- Granted: 2016-12-13
- Earliest claimed: 2009-02-21
- Assignees: Covidien LP
- Applicants: Covidien LP
- Inventors: Nadya Belcheva; Ferass Abuzaina; Amin Elachchabi; Mbiya Kapiamba; Ahmad Robert Hadba
- Web page: https://patentgrep.com/patent/US9517291B2

## CPC

- C08J 7/12: Chemical modification
- A61L 31/04: Macromolecular materials
- A61L 31/042: {Polysaccharides}
- A61L 31/043: {Proteins; Polypeptides; Degradation products thereof}
- A61L 31/044: {Collagen}
- A61L 31/048: {obtained by reactions only involving carbon-to-carbon unsaturated bonds (A61L31/041 takes precedence)}
- A61L 31/06: obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds {(A61L31/041 takes precedence)}
- A61L 31/14: Materials characterised by their function or physical properties {, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials}
- A61L 31/148: {Materials at least partially resorbable by the body}
- A61L 31/16: Biologically active materials, e.g. therapeutic substances {(A61L31/047 takes precedence)}
- A61L 33/06: Use of macromolecular materials (grafting of a monomer onto the substrate A61L33/0088)
- C08J 7/14: with acids, their salts or anhydrides
- A61L 2400/18: Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
- C08J 2300/16: Biodegradable polymers
- Y10T 442/20: Coated or impregnated woven, knit, or nonwoven fabric which is not [a] associated with another preformed layer or fiber layer or, [b] with respect to woven and knit, characterized, respectively, by a particular or differential weave or knit, wherein the coating or impregnation is neither a foamed material nor a free metal or alloy layer
- C08J: WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H (working, e.g. shaping, of plastics B29)
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)
- Y10T: TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION

## Abstract

Implantable biocompatible polymeric medical devices include a substrate with an acid or base-modified surface which is subsequently modified to include click reactive members.

## Claims

### Claim 1

A method of preparing a medical device having an activated surface, the method comprising:
acid-treating at least a portion of a surface of a polymeric medical device to obtain hydrolysis; and
attaching one or more click reactive members to the acid-treated surface of the medical device, wherein the click reactive members are selected from the group consisting of thiols, azides, alkynes, and alkenes.

### Claim 2 (depends on 1)

The method according to claim 1, wherein the acid is selected from the group consisting of HCl, HCl3, HCl4, H2SO3, H2SO4, H3PO4, HI, HIO3, HBr, lactic acid and glycolic acid.

### Claim 3 (depends on 1)

The method according to claim 1, wherein the click reactive member is selected from the group consisting of thiols and alkenes.

### Claim 4 (depends on 1)

The method according to claim 1, wherein the click reactive members are selected from the group consisting of azides and alkynes.

### Claim 5 (depends on 1)

The method according to claim 1, wherein the medical device is selected from the group consisting of monofilament sutures, multifilament sutures, surgical meshes, ligatures, sutures, staples, slings, patches, foams, pellicles, films, barriers, stents, catheters, and inflatable balloons.

### Claim 6 (depends on 1)

The method according to claim 1, wherein the medical device is a surgical mesh.

### Claim 7 (depends on 1)

The method according to claim 1, wherein the medical device comprises a biodegradable polymer selected from collagen, cellulose, poly (amino acids), polysaccharides, hyaluronic acid, copolymers and combinations thereof.

### Claim 8 (depends on 1)

The method according to claim 1, wherein the medical device comprises a non-degradable polymer selected from fluorinated polymers, polyolefins, polyamides, polyurethanes, silicones, polyaryletherketone, copolymers and combinations thereof.

### Claim 9 (depends on 1)

The method according to claim 1, wherein acid-treating at least a portion of a surface of a medical device is conducted at a temperature between 0° C. and a glass transition temperature of a material of the medical device.

### Claim 10 (depends on 1)

The method according to claim 1, wherein the medical device comprises polybutester.

### Claim 11 (depends on 1)

The method according to claim 1, wherein the medical device comprises nylon.

### Claim 12 (depends on 1)

The method according to claim 1, wherein the medical device comprises ultra high molecular weight polyethylene.