# US 9,517,269 B1 · Stable pentobarbital formulation

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- Number: US 9,517,269 B1
- Document ID: US9517269B1
- Status: Granted
- Kind: B1
- Application number: 14/617,404
- Filed: 2015-02-09
- Granted: 2016-12-13
- Earliest claimed: 2013-10-01
- Assignees: Akorn, Inc.
- Applicants: Akorn, Inc.
- Inventors: Sean E. Brynjelsen; Biswajit Pati
- Web page: https://patentgrep.com/patent/US9517269B1

## CPC

- A61K 47/10: Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A61K 9/0019: {Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner (non-active ingredients are additionally classified in A61K47/00)}
- A61K 31/515: Barbituric acids; Derivatives thereof, e.g. sodium pentobarbital
- Y02A 50/30: Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- Y02A: TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE

## Abstract

The present invention relates to a pentobarbital formulation with greater stability and fewer impurities. In particular, the formulation may be an aqueous formulation containing 50 mg/mL pentobarbital sodium, 50% glycol, and 10% alcohol, at a pH of 9.4.

## Claims

### Claim 1

A composition comprising 50 mg/mL of a pentobarbital, 50% (v/v) propylene glycol, 10% (v/v) ethanol, and water, wherein the pH of the composition is 9.0-9.5.

### Claim 2 (depends on 1)

The composition of claim 1, wherein the pentobarbital is a sodium or calcium salt of pentobarbital.

### Claim 3 (depends on 2)

The composition of claim 2, wherein the pentobarbital is a sodium salt of pentobarbital.

### Claim 4 (depends on 1)

The composition of claim 1, wherein the pH is 9.4.