# US 9,517,249 B2 · Antioxidant dietary supplement and related method

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- Number: US 9,517,249 B2
- Document ID: US9517249B2
- Status: Granted
- Kind: B2
- Application number: 14/088,765
- Filed: 2013-11-25
- Published: 2014-05-29
- Granted: 2016-12-13
- Earliest claimed: 2012-11-26
- Assignees: Access Business Group International LLC
- Applicants: Access Business Group International LLC
- Inventors: David J. Fast; Jennifer Patterson; Arun Rajgopal; Donald J. Pusateri; Kevin W. Gellenbeck; Jeffrey Scholten; Steven R. Missler; Russell K. Randolph; Jennifer Chuang; Yumei Lin; Valiantsina Kazlova
- Web page: https://patentgrep.com/patent/US9517249B2

## CPC

- A61K 36/9066: Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
- A23L 2/52: Adding ingredients (adding preservatives A23B70/10)
- A23L 33/105: Plant extracts, their artificial duplicates or their derivatives
- A23L 33/15: Vitamins
- A23L 33/155: Vitamins A or D
- A23L 33/16: Inorganic salts, minerals or trace elements
- A61K 31/352: condensed with carbocyclic rings, e.g. methantheline {(cannabinoids A61K31/658)}
- A61K 36/31: Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
- A61K 36/53: Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A61P 39/00: General protective or antinoxious agents
- A61P 39/06: Free radical scavengers or antioxidants
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A23V 2002/00: Food compositions, function of food ingredients or processes for food or foodstuffs
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A23V: INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION

## Abstract

A supplement including a blend of turmeric, quercetin and rosemary, or holy basil, wasabi, and broccoli seed extract which are present in a balanced and predetermined ratio, and which stimulate the Antioxidant Response Element (ARE), Quinone Reductase, and/or induce related gene expression, for example, heme oxygenase-1 (HMOX-1) expression. The blend of ingredients can be formed as or in a dietary supplement adapted for administration to a subject. The dietary supplement can be formulated so that the turmeric, quercetin and rosemary are present in a predetermined ratio of 1:3:5, or holy basil, wasabi, and broccoli seed extract in a predetermined ratio of 1:1:0.2. Additional ingredients can be included in the supplement. The supplement can synergistically affect natural antioxidant response pathways within cells of a subject to whom the supplement is administered. A related method of use is also provided.

## Claims

### Claim 1

A method for stimulating an antioxidant response element (ARE) and/or inducing Heme Oxygenase-1 (HOX-1) expression in the cells of a human in need thereof, comprising orally administering to said human an effective amount of a dietary supplement comprising turmeric, quercetin and rosemary, wherein the turmeric, quercetin and rosemary are present in the supplement in a ratio of 1:3:5, respectively.

### Claim 2 (depends on 1)

The method of claim 1 wherein the orally administering step includes administering to the human the dietary supplement in the form of at least one of a capsule, tablet, and liquid form.

### Claim 3 (depends on 1)

The method of claim 1 wherein turmeric in an amount of 33 mg, quercetin in an amount of 100 mg, and rosemary in an amount of 167 mg, are administered during the orally administering step.

### Claim 4 (depends on 1)

The method of claim 1 wherein turmeric in an amount of 66 mg, quercetin in an amount of 200 mg, and rosemary in an amount of 333 mg, are administered during the orally administering step.

### Claim 5 (depends on 1)

The method of claim 1 further comprising orally administering at least one of vitamins and minerals with the dietary supplement to the human.

### Claim 6 (depends on 1)

The method of claim 1, wherein said orally administering to said human also decreases urinary level of 8-isoprostane and/or blood serum level of catalase in the human.

### Claim 7 (depends on 1)

The method of claim 1, wherein said orally administering to said human also increases production of at least one of glutathione peroxidase and superoxide dismutase in the human.

### Claim 8 (depends on 1)

The method of claim 1 wherein the turmeric is at least one of derived and extracted from Curcuma longa.

### Claim 9 (depends on 1)

The method of claim 1 wherein the quercetin is at least one of derived and extracted from at least one of apples, onions, parsley, sage, tea, blueberries, blackberries, bilberries, Fava d'anta and Sophora japonica.

### Claim 10 (depends on 1)

The method of claim 1 wherein the rosemary is at least one of derived and extracted from Rosmarinus officinalis.