# US 9,517,222 B2 · Method for the treatment of senile dementia of the Alzheimer's type

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- Number: US 9,517,222 B2
- Document ID: US9517222B2
- Status: Granted
- Kind: B2
- Application number: 14/674,705
- Filed: 2015-03-31
- Published: 2015-10-29
- Granted: 2016-12-13
- Earliest claimed: 2007-02-08
- Assignees: Phenomenome Discoveries Inc.
- Applicants: Phenomenome Discoveries Inc.
- Inventors: Dayan Burke Goodenowe
- Web page: https://patentgrep.com/patent/US9517222B2

## CPC

- A61K 31/232: having three or more double bonds, e.g. etretinate
- A61K 31/661: Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion {or mevinphos}
- A61K 31/6615: Compounds having two or more esterified phosphorus acid groups, e.g. inositol triphosphate, phytic acid
- A61P 3/00: Drugs for disorders of the metabolism (of the blood or the extracellular fluid A61P7/00)
- A61P 3/06: Antihyperlipidemics
- A61P 25/28: for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The present invention relates to the treatment of Senile Dementia of the Alzheimer's Type (SDAT) by administering to the patient and effective amount of a compound selected from the group consisting of: 1-alkyl, 2-acyl-glyceraldehyde-3-phosphate (G3P); 1-alkyl, 2-acyl-glycerol; and 1-alkyl, 2-acyl-glycerylphosphatidylethanolamine (CGPE) or a pharmaceutically acceptable salt thereof.

## Claims

### Claim 1

A method for the treatment of senile dementia of the Alzheimer's Type (SDAT) by administering to a patient in need thereof a therapeutically effective amount of a compound selected from the group consisting of 1-alkyl, 2-acyl-glyceraldehyde-3-phosphate (G3P); 1-alkyl, 2-acyl-glycerol; and 1-alkyl, 2-acyl-glycerylphosphatidylethanolamine (GPE);
or a pharmaceutically acceptable salt thereof.

### Claim 2 (depends on 1)

The method of claim 1, wherein the compound is a 1-alkyl, 2-acyl-glycerol.

### Claim 3 (depends on 1)

The method of claim 1, wherein the side chains include a saturated or unsaturated fatty acid of the following type:
16:0, 18:0, 18:1, 18:2, or 18:3 as alkyl at the sn-1 position, and/or
16:0, 18:0, 18:1, 18:2, 18:3, 20:4, 20:5, 20:6, 22:4, 22:5, 22:6, 24:4, 24:5, or 24:6 as acyl at the sn-2 position.