# US 9,517,221 B2 · (2R)-2-propyloctanoic acid for functional brain disease

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- Number: US 9,517,221 B2
- Document ID: US9517221B2
- Status: Granted
- Kind: B2
- Application number: 12/282,298
- Filed: 2007-03-08
- Published: 2009-02-05
- Granted: 2016-12-13
- Earliest claimed: 2006-03-09
- Assignees: Ono Pharmaceutical Co., Ltd.
- Applicants: Rika Shinagawa; Yoshifumi Kagamiishi; Taiji Shimoda
- Inventors: Rika Shinagawa; Yoshifumi Kagamiishi; Taiji Shimoda
- Web page: https://patentgrep.com/patent/US9517221B2

## CPC

- A61K 31/20: having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A61P 1/04: for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A61P 25/00: Drugs for disorders of the nervous system
- A61P 25/22: Anxiolytics
- A61P 25/24: Antidepressants
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

[Problem to be solved] Provision of an agent for preventing or treating a functional brain disease and/or inhibiting symptom development of the same. [Means for solving the problems] An agent for preventing or treating a functional brain disease and/or inhibiting symptom development of the same, which comprises (2R)-2-propyloctanoic acid or a salt thereof. The agent for preventing or treating a functional brain disease and/or inhibiting symptom development of the same, which comprises (2R)-2-propyloctanoic acid or a salt thereof, can be safely administered to patients of, for example, functional brain diseases such as depression, menopausal mood disorder, perimenopausal mood disorder, panic disorder, irritable bowel syndrome, social anxiety disorder, post-traumatic stress disorder or the like, and also can show excellent effects.

## Claims

### Claim 1

A method for treating a functional brain disease and/or inhibiting symptom development of the same, which comprises administering an effective amount of (2R)-2-propyloctanoic acid or a salt thereof to a mammal in need thereof, wherein said functional brain disease is anxiety disorder.

### Claim 2 (depends on 1)

The method according to claim 1, wherein the effective amount of (2R)-2-propyloctanoic acid or a salt thereof is 1 mg to 5000 mg.

### Claim 3 (depends on 1)

The method according to claim 1, wherein the anxiety disorder is panic disorder, social anxiety disorder and/or post-traumatic stress disorder.

### Claim 4 (depends on 1)

The method according to claim 1, wherein the (2R)-2-propyloctanoic acid or a salt thereof is used in combination with an anxiolytic drug.