# US 9,517,197 B1 · Toothpaste composition containing ganoderma lucidum component and preparation method thereof

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- Number: US 9,517,197 B1
- Document ID: US9517197B1
- Status: Granted
- Kind: B1
- Application number: 15/182,600
- Filed: 2016-06-15
- Granted: 2016-12-13
- Earliest claimed: 2015-12-15
- Assignees: Jiangsu Daocheng Biotechnology Co., Ltd.
- Applicants: Jiangsu Daocheng Biotechnology Co., Ltd
- Inventors: Zhengguo Gu; Yangchun Chen; Wei Zhang
- Web page: https://patentgrep.com/patent/US9517197B1

## CPC

- A61K 8/8152: {Homopolymers or copolymers of esters, e.g. (meth)acrylic acid esters; Compositions of derivatives of such polymers}
- A61K 8/24: Phosphorous; Compounds thereof
- A61K 8/25: Silicon; Compounds thereof
- A61K 8/345: {containing more than one hydroxy group}
- A61K 8/368: with carboxyl groups directly bound to carbon atoms of aromatic rings
- A61K 8/39: Derivatives containing from 2 to 10 oxyalkylene groups
- A61K 8/463: {containing sulfuric acid derivatives, e.g. sodium lauryl sulfate}
- A61K 8/49: containing heterocyclic compounds
- A61K 8/731: {Cellulose; Quaternized cellulose derivatives}
- A61K 8/86: Polyethers
- A61K 8/9789: Magnoliopsida [dicotyledons]
- A61P 1/02: Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A61P 7/04: Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
- A61P 31/02: Local antiseptics
- A61P 31/04: Antibacterial agents
- A61Q 11/00: Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
- A61K 2800/5922: At least two compounds being classified in the same subclass of A61K8/18
- A61K 2800/80: Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

The present invention discloses a preparation method for toothpaste composition containing ganoderma lucidum component, wherein the ganoderma lucidum component is sporoderm-broken ganoderma lucidum spore, it comprises the following steps: (1) dissolve water, sorbitol, PEG-8, propylene glycol, sodium saccharine, sodium benzoate and the extract of opuntia in a toothpaste-making pot; (2) premix calcium hydrogen phosphate, hydrated silica, sodium lauryl sulfate, cellulose gum, hydroxyethyl cellulose, sporoderm-broken ganoderma lucidum spore, Panax notoginseng powder, and radix scutellariae root powder in powder tank evenly to form a mixture; (3) stir the mixture obtained in step (2) under vacuum and inhale into the toothpaste-making pot of step (1); control the vacuum degree at minus 0.098 to minus 0.1 Mpa and stir for 15 minutes; (4) inhale the essence into the toothpaste-making pot, stir for 10 minutes, and discharge. The preparation method of the present invention is of simple technique, easy operation, and high efficiency and the obtained toothpaste composition containing ganoderma lucidum component has good using effect.

## Claims

### Claim 1

A preparation method for toothpaste composition containing ganoderma lucidum component, wherein the ganoderma lucidum component is sporoderm-broken ganoderma lucidum spore, characterized in that it comprises the following steps:
(1) dissolve water, sorbitol, PEG-8, propylene glycol, sodium saccharine, sodium benzoate and the extract of opuntia in a toothpaste-making pot;
(2) premix calcium hydrogen phosphate, hydrated silica, sodium lauryl sulfate, cellulose gum, hydroxyethyl cellulose, sporoderm-broken ganoderma lucidum spore, Panax notoginseng powder, and radix scutellariae root powder in powder tank evenly to form a mixture;
(3) stir the mixture obtained in step (2) under vacuum and inhale into the toothpaste-making pot of step (1); control the vacuum degree at minus 0.098 to minus 0.1 Mpa and stir for 10-20 minutes;
(4) inhale the essence into the toothpaste-making pot, stir for 10-20 minutes, and discharge.

### Claim 2 (depends on 1)

The preparation method for toothpaste composition containing ganoderma lucidum component according to claim 1, the parts by weight of each composition added in step (1) is: 30˜40 parts of water, 10˜20 parts of sorbitol, 0.5˜1.5 parts of PEG-8, 0.5˜1.5 parts of propylene glycol, 0.1˜0.5 parts of sodium saccharine, 0.3˜0.8 parts of sodium benzoate and 0.1˜0.5 parts of the extract of opuntia.

### Claim 3 (depends on 2)

The preparation method for toothpaste composition containing ganoderma lucidum component according to claim 2, the parts by weight of each composition added in step (2) is: 40˜65 parts of calcium hydrogen phosphate, 0.5˜1.5 parts of hydrated silica, 0.5˜1.5 parts of sodium lauryl sulfate, 0.3˜0.8 parts of cellulose gum, 0.1˜0.5 parts of hydroxyethyl cellulose, 0.1˜0.5 parts of sporoderm-broken ganoderma lucidum spore, 0.1˜0.5 parts of Panax notoginseng powder and 0.1˜0.5 parts of radix scutellariae root powder.

### Claim 4 (depends on 3)

The preparation method for toothpaste composition containing ganoderma lucidum component according to claim 3, characterized in that the parts by weight of each composition added in step (1) is: 33.5 parts of water, 10 parts of sorbitol, 1 part of PEG-8, 1 part of propylene glycol, 0.2 parts of sodium saccharine, 0.5 parts of sodium benzoate and 0.2 parts of the extract of opuntia; and the parts by weight of each composition added in step (2) is: 50 parts of calcium hydrogen phosphate, 1 part of hydrated silica, 1 part of sodium lauryl sulfate, 0.5 parts of cellulose gum, 0.1 parts of hydroxyethyl cellulose, 0.1 parts of sporoderm-broken ganoderma lucidum spore, 0.2 parts of Panax notoginseng powder and 0.2 parts of radix scutellariae root powder.

### Claim 5 (depends on 4)

The preparation method for toothpaste composition containing ganoderma lucidum component according to claim 4, characterized in that stir for 15 minutes in step (3) and stir for 10 minutes in step (4).

### Claim 6 (depends on 1)

The preparation method for toothpaste composition containing ganoderma lucidum component according to claim 1, characterized in that modified grafting is carried out to sporoderm-broken ganoderma lucidum spore before step (2), the modified grafting process is to carry out grafting reaction between sporoderm-broken ganoderma lucidum spore and starch in water and alcohol under the existence of grafting agent, wherein the weight ratio of water, alcohol, sporoderm-broken ganoderma lucidum spore and starch is 1:1:3:1˜4, processing temperature is 35˜55 DEG C and stirring time is 2˜3 h, and the modified sporoderm-broken ganoderma lucidum spore is obtained.

### Claim 7 (depends on 6)

The preparation method for toothpaste composition containing ganoderma lucidum component according to claim 6, characterized in that the grafting agent in modified grafting process is acrylate epoxy resin, and the usage amount is 5%—10% of total volume.

### Claim 8 (depends on 6)

The preparation method for toothpaste composition containing ganoderma lucidum component according to claim 6, characterized in that the usage amount of the grafting agent in modified grafting process is 8% of total volume.

### Claim 9

A toothpaste composition containing ganoderma lucidum component, comprising following compositions in parts by weight: 30˜40 parts of water, 10˜20 parts of sorbitol, 0.5˜1.5 parts of PEG-8, 0.5˜1.5 parts of propylene glycol, 0.1˜0.5 parts of sodium saccharine, 0.3˜0.8 parts of sodium benzoate, 0.1˜0.5 parts of the extract of opuntia, 40˜65 parts of calcium hydrogen phosphate, 0.5˜1.5 parts of hydrated silica, 0.5˜1.5 parts of sodium lauryl sulfate, 0.3˜0.8 parts of cellulose gum, 0.1˜0.5 parts of hydroxyethyl cellulose, 0.1˜0.5 parts of sporoderm-broken ganoderma lucidum spore, 0.1˜0.5 parts of Panax notoginseng powder and 0.1˜0.5 parts of radix scutellariae root powder.

### Claim 10 (depends on 9)

The toothpaste composition containing ganoderma lucidum component according to claim 9, characterized in that it comprises 33.5 parts of water, 10 parts of sorbitol, 1 part of PEG-8, 1 part of propylene glycol, 0.2 parts of sodium saccharine, 0.5 parts of sodium benzoate, 0.2 parts of the extract of opuntia, 50 parts of calcium hydrogen phosphate, 1 part of hydrated silica, 1 part of sodium lauryl sulfate, 0.5 parts of cellulose gum, 0.1 parts of hydroxyethyl cellulose, 0.1 parts of sporoderm-broken ganoderma lucidum spore, 0.2 parts of Panax notoginseng powder and 0.2 parts of radix scutellariae root powder.