# US 9,517,190 B2 · Coated titanium dioxide to reduce the whitening effect on skin > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 9,517,190 B2 - Document ID: US9517190B2 - Status: Granted - Kind: B2 - Application number: 14/661,487 - Filed: 2015-03-18 - Published: 2015-09-24 - Granted: 2016-12-13 - Earliest claimed: 2014-03-18 - Assignees: Symrise AG - Applicants: Symrise AG - Inventors: William Johncock; Simone Peters; Martina Issleib; Jürgen Claus - Web page: https://patentgrep.com/patent/US9517190B2 ## CPC - A61K 8/29: Titanium; Compounds thereof - A61K 8/0241: {Containing particulates characterized by their shape and/or structure (see also A61K8/04, A61K8/11, and A61K8/14, further aspects are classified in A61K2800/40 and subcodes)} - A61K 8/26: Aluminium; Compounds thereof - A61K 8/37: Esters of carboxylic acids - A61K 9/5021: {Organic macromolecular compounds} - A61K 9/5089: {Processes} - A61P 17/16: Emollients or protectives, e.g. against radiation - A61P 17/18: Antioxidants, e.g. antiradicals (preparations for protection against sunlight A61Q17/00) - A61Q 17/04: Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations - C09C 1/3661: {Coating} - C09C 1/3669: {Treatment with low-molecular organic compounds} - C09C 1/3692: {Combinations of treatments provided for in groups C09C1/3615 - C09C1/3684} - A61K 2800/413: Nanosized, i.e. having sizes below 100 nm - A61K 2800/622: by organic compounds - A61K 2800/63: More than one coating - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS - A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS - C09C: TREATMENT OF INORGANIC MATERIALS, OTHER THAN FIBROUS FILLERS, TO ENHANCE THEIR PIGMENTING OR FILLING PROPERTIES (treatment of materials specially adapted to enhance their filling properties in mortars, concrete or artificial stone C04B14/00, C04B18/00, C04B20/00); PREPARATION OF CARBON BLACK {; PREPARATION OF INORGANIC MATERIALS WHICH ARE NO SINGLE CHEMICAL COMPOUNDS AND WHICH ARE MAINLY USED AS PIGMENTS OR FILLERS} ## Abstract The present invention relates to coated titanium dioxide particles, wherein at least one coating layer comprises an ester made from a mixture of fatty alcohol and C6 to C12 aliphatic acids as coating material. ## Claims ### Claim 1 Coated titanium dioxide particles, wherein at least one coating layer comprises an ester made from a mixture of C12 to C30 fatty alcohols and C6 to C12 aliphatic acids as coating material. ### Claim 2 (depends on 1) The particles of claim 1, wherein the coating material is at least a C16 -C18 nonanoate derivative or mixture thereof. ### Claim 3 (depends on 1) The particles of claim 1, wherein the coating material comprises cetearyl nonoate and/or cetearyl isononoate. ### Claim 4 (depends on 1) The particles of claim 1, wherein the titanium dioxide particles comprise one or more additional coating layer, whereby the coating material is selected from the group consisting of silica (SiO2), aluminium hydroxide (Al2(OH)3, aluminium oxide (Al2O3), sodium hexametaphosphate (Na(PO3)6), sodium metaphosphate (Na(PO3)n, aluminium stearate, stearic acid, lauric acid, dimethicone, or mixtures thereof. ### Claim 5 (depends on 1) The particles of claim 1, wherein the loading capacity of the coating material comprising a mixture of fatty acid esters, on the particles is in the range from 5 to 25%, referring to the total weight of a particle. ### Claim 6 (depends on 4) The particles of claim 4, wherein the loading capacity of the coating material is in the range of 5 to 15 wt.%, referring to the total weight of a particle. ### Claim 7 (depends on 1) The particles of claim 1, wherein at least one dimension of individual crystals making up agglomerates of the particles is <100 nm. ### Claim 8 (depends on 1) A cosmetic and/or pharmaceutical preparation comprising the coated titanium dioxide particles of claim 1. ### Claim 9 (depends on 8) The preparation of claim 8, wherein the amount of the titanium dioxide particles is in the range of 0.5 to 25%, referring to the total preparation. ### Claim 10 (depends on 8) The preparation of claim 8, further comprising at least one UV filter in an amount from 0.1 to 65.0%, referring to the total amount of all UV filters, referring to the total amount of the preparation. ### Claim 11 (depends on 10) The preparation of claim 10, wherein the UV filters are selected from the group consisting of: Avobenzone, Homosalate, Octisalate, Octocrylene, 2-Ethylhexyl p-methoxycinnamate, Isoamyl p-methoxycinnamate, 3-(4′-methylbenzylidene)-d,l-camphor, 2,4,6-trianilino(p-carbo-2′-ethylhexyl-1′-oxy)-1,3,5-triazine, Tris-Biphenyl Triazine, Diethylhexyl Butamido Triazone, Benzylidenemalonate-polysiloxane, 2-Ethylhexyl 4-dimethylaminobenzoate, Drometrizole Trisiloxane, Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine, 2,2′-Methylenebis(6-(2H-benztriazol-2-yl)-4-1,1,3,3-tetramethylbutyl)-phenol), Diethylamino Hydroxybenzoyl Hexyl Benzoate, Disodium Phenyl-dibenzimidazole Tetrasulphonate and its salts, Phenyibenzimidazole- sulphonic Acid and its salts, Terephthalyiidene Dicamphor Sulfonic Acid and its salts, Benzophenone-4 and its salts, Benzophenone-3, Menthyl anthranilate, Padimate O, Zinc oxide, and their mixtures. ### Claim 12 (depends on 8) The preparation of claim 8, further comprising auxiliaries and additives selected from surfactants, oil bodies, co-emulsifiers, superfatting agents, pearlising waxes, consistency factors, polymers, silicone compounds, stabilizers, antidandruff agents, film formers, swelling agents, hydrotropes, preservatives, solubilizers, complexing agents, reducing agents, alkalising agents, perfume oils, dyes, fats, moisturizers, antioxidants, antiperspirants, insect repellants, self-tanning agents, tyrosine inhibitors (depigmenting agents), bodying agents, antimicrobial agents, antifoams, aqueous and non-aqueous plant extracts and the like as additional auxiliaries and additives. ### Claim 13 (depends on 8) The preparation of claim 8, having a sun protection factor of at least 2. ### Claim 14 (depends on 8) The preparation of claim 8, having a UVA protection factor of at least 2, measured by the Colipa Method for in vitro determination of UVA protection, 2011. ### Claim 15 (depends on 8) The preparation of claim 8, which is a dermatological preparation selected from the group consisting of creams, hydrogels, hydrodispersion gels, oil gels, lotions, balsams.