# US 9,517,187 B2 · Implant coated with net-shaped or island-shaped low-crystallized hydroxyapatite and method for coating same > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 9,517,187 B2 - Document ID: US9517187B2 - Status: Granted - Kind: B2 - Application number: 13/378,029 - Filed: 2010-05-18 - Published: 2012-04-12 - Granted: 2016-12-13 - Earliest claimed: 2009-06-18 - Assignees: Osstemimplant Co., Ltd. - Applicants: Kyung Won Ha; Gyu Ok Choi - Inventors: Kyung Won Ha; Gyu Ok Choi - Web page: https://patentgrep.com/patent/US9517187B2 ## CPC - A61B 17/84: Fasteners therefor {or fasteners being internal fixation devices} - A61C 8/0013: {with a surface layer, coating} - A61K 6/20: Protective coatings for natural or artificial teeth, e.g. sealings, dye coatings or varnish - A61K 6/838: Phosphorus compounds, e.g. apatite - A61K 6/84: comprising metals or alloys - A61L 27/06: Titanium or titanium alloys - A61L 27/32: Phosphorus-containing materials, e.g. apatite - C23C 22/22: containing alkaline earth metal cations - C23F 1/26: for etching refractory metals - A61B 2017/00004: {(bio)absorbable, (bio)resorbable or resorptive} - A61B 2017/00526: {Methods of manufacturing} - A61B 2017/00933: {bone or bone-like} - A61B 2017/00995: {having a thin film} - A61L 2420/02: Methods for coating medical devices - A61L 2430/02: for reconstruction of bones; weight-bearing implants - A61L 2430/12: for dental implants or prostheses - Y10T 428/265: 1 mil or less - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - A61C: DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE (non-driven toothbrushes A46B; {tongue scrapers A61B17/24;} preparations for dentistry A61K6/00; preparations for cleaning the teeth or mouth A61K8/00, A61Q11/00) - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K) - C23C: COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL (making metal-coated products by extrusion B21C23/22; covering with metal by connecting pre-existing layers to articles, see the relevant places, e.g. B21D39/00, B23K; metallising of glass C03C; metallising mortars, concrete, artificial stone, ceramics or natural stone C04B41/00; enamelling of, or applying a vitreous layer to, metals C23D; treating metal surfaces or coating of metals by electrolysis or electrophoresis C25D; single-crystal film growth C30B; by metallising textiles D06M11/83; decorating textiles by locally metallising D06Q1/04) - C23F: NON-MECHANICAL REMOVAL OF METALLIC MATERIAL FROM SURFACE (working metal by laser beams B23K26/00; desurfacing by applying flames B23K7/00; working of metal by electro-erosion B23H; producing decorative effects by removing surface material, e.g. by engraving, by etching, B44C1/22; electrolytic etching or polishing C25F); INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL; MULTI-STEP PROCESSES FOR SURFACE TREATMENT OF METALLIC MATERIAL INVOLVING AT LEAST ONE PROCESS PROVIDED FOR IN CLASS C23 AND AT LEAST ONE PROCESS COVERED BY SUBCLASS C21D OR C22F OR CLASS C25 - Y10T: TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION ## Abstract The present disclosure relates to a method for coating a surface of a titanium implant with low crystalline hydroxyapatite having network- or island-like morphology and to an implant coated by such method. ## Claims ### Claim 1 A method for coating a titanium or titanium alloy implant with hydroxyapatite, said method comprising: pretreating a surface of a titanium or titanium alloy implant, mixing a phosphate ion solution with a calcium ion solution to prepare a calcium phosphate solution, and dipping and storing the titanium or titanium alloy implant in the calcium phosphate solution for 1 hour to provide a titanium or titanium alloy implant having a double surface with co-exposure of a network- or island-like coating of hydroxyapatite and the implant surface. ### Claim 2 (depends on 1) The method according to claim 1, wherein the pretreatment step includes ultrasonic treatment of the titanium or titanium alloy implant in distilled water, a calcium ion solution, a phosphate ion solution or a calcium phosphate solution for 1 minute or more. ### Claim 3 (depends on 2) The method according to claim 2, further comprising washing the titanium or titanium alloy implant with an acidic solution before the ultrasonic treatment of the implant. ### Claim 4 (depends on 3) The method according to claim 3, wherein the acidic solution is a nitric acid solution. ### Claim 5 (depends on 1) The method according to claim 1, wherein the phosphate ion solution is prepared by dissolving ammonium phosphates, sodium phosphates or potassium phosphates in distilled water. ### Claim 6 (depends on 1) The method according to claim 1, wherein the calcium ion solution is prepared by dissolving calcium nitrate or calcium chloride in distilled water. ### Claim 7 (depends on 1, 2) The method according to claim 1 or 2, wherein a reaction temperature in the step of dipping and storing the titanium or titanium alloy implant in the calcium phosphate solution is in the range of 15° C. to 30° C. ### Claim 8 (depends on 1) The method according to claim 1, wherein the pretreatment step is selected from the group consisting of an RBM (Resorbable Blasting Media) treatment, an SLA (Sand-blasted Large grit, and Acid etched) treatment, a heat treatment at 300° C. or higher, an anodization, and a heat treatment after an acid or base treatment. ### Claim 9 (depends on 1) The method according to claim 1, wherein the calcium phosphate solution has a concentration of 1.0 mM to 10 mM. ### Claim 10 (depends on 1) The method according to claim 1, wherein the pretreatment step includes ultrasonic treatment of the titanium or titanium alloy implant in distilled water, a calcium ion solution, a phosphate ion solution or a calcium phosphate solution for 1 minute, after RBM (Resorbable Blasting Media) treatment, an SLA (Sand-blasted Large grit, and Acid etched) treatment, a heat treatment at 300° C. or higher, an anodization, or a heat treatment after an acid or base treatment.