# US 9,517,067 B2 · System and method for satellite drug delivery

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 9,517,067 B2
- Document ID: US9517067B2
- Status: Granted
- Kind: B2
- Application number: 14/530,853
- Filed: 2014-11-03
- Published: 2015-02-19
- Granted: 2016-12-13
- Earliest claimed: 2010-11-29
- Assignees: Covidien LP
- Applicants: Covidien LP
- Inventors: Nadya D. Belcheva; Joshua Stopek
- Web page: https://patentgrep.com/patent/US9517067B2

## CPC

- A61B 17/0684: {having a forming anvil staying above the tissue during stapling}
- A61K 9/0024: {Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue (compositions for intravenous administration, normal injectable solutions or dispersions for, e.g. subcutaneous administration A61K9/0019; brain implants A61K9/0085; (coated) prostheses, catheters or stents A61L)}
- A61L 17/005: {containing a biologically active substance, e.g. a medicament or a biocide}
- A61L 27/54: Biologically active materials, e.g. therapeutic substances {(A61L27/227 takes precedence)}
- A61L 31/16: Biologically active materials, e.g. therapeutic substances {(A61L31/047 takes precedence)}
- A61M 37/00: Other apparatus for introducing media into the body (for reproduction or fertilisation A61B17/425; apparatus for iontophoresis or cataphoresis A61N1/30); Percutany, i.e. introducing medicines into the body by diffusion through the skin (salt baths A61H33/04)
- A61P 7/02: Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A61P 7/04: Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
- A61P 23/00: Anaesthetics
- A61P 29/00: Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P 31/00: Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P 35/00: Antineoplastic agents
- A61B 17/0682: {for applying U-shaped staples or clamps, e.g. without a forming anvil}
- A61B 17/072: for applying a row of staples in a single action, e.g. the staples being applied simultaneously
- A61B 2017/00004: {(bio)absorbable, (bio)resorbable or resorptive}
- A61B 2017/00893: {pharmaceutically effective}
- A61B 2090/3991: {having specific anchoring means to fixate the marker to the tissue, e.g. hooks}
- A61L 2300/402: Anaestetics, analgesics, e.g. lidocaine
- A61L 2300/404: Biocides, antimicrobial agents, antiseptic agents
- A61L 2300/416: Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
- A61L 2300/42: Anti-thrombotic agents, anticoagulants, anti-platelet agents
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)
- A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)}
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The present disclosure is directed to an implantable repository including a housing comprising at least one bioactive agent and at least one attachment member coupled to the housing, the at least one attachment member configured to couple the implantable repository to at least one of a medical device and a tissue surface.

## Claims

### Claim 1

A medical instrument comprising:
an elongated shaft having a proximal end and a distal end;
a handle assembly coupled to the proximal end of the elongated shaft, the handle assembly including a trigger; and
an end effector assembly disposed at the distal end of the elongated shaft, the end effector assembly actuatable by the trigger and including:
a cartridge assembly having at least one implantable repository; and
an anvil assembly having a plurality of fasteners that are separate from the at least one implantable repository,
wherein upon actuation of the trigger, at least one of the plurality of fasteners engages the at least one implantable repository and is ejected from the cartridge assembly along with the at least one implantable repository.

### Claim 2 (depends on 1)

The medical instrument according to claim 1, wherein the at least one implantable repository includes:
a capsule defining a housing having at least one enclosed lumen therein, the lumen having at least one bioactive agent disposed therein; and
at least one loop attachment member coupled to the housing, the at least one attachment member configured to couple the implantable repository to at least one of the plurality of fasteners during firing thereof.

### Claim 3 (depends on 2)

The medical instrument according to claim 2, wherein the housing comprises at least one biodegradable polymer.

### Claim 4 (depends on 3)

The medical instrument according to claim 3, wherein the at least one biodegradable polymer is selected from the group consisting of aliphatic polyesters, polyamides, polyamines, polyalkylene oxalates, poly(anhydrides), polyamidoesters, copoly(ether-esters), poly(carbonates), poly(hydroxyalkanoates), polyimide carbonates, poly(imino carbonates), polyorthoesters, polyoxaesters, polyphosphazenes, poly(propylene fumarates), polyurethanes, polymer drugs, protein modified bioabsorbable polymers, and combinations thereof.

### Claim 5 (depends on 2)

The medical instrument according to claim 2, wherein the at least one loop attachment member comprises a first end and a second end, wherein at least one of the first end or the second end is detachable from the housing.

### Claim 6 (depends on 2)

The medical instrument according to claim 2, wherein the at least one bioactive agent is selected from the group consisting of an anesthetic agent, an antibiotic agent, an antimicrobial agent, an anticoagulant agent, a hemostatic agent, an anti-adhesive agent, a chemotherapeutic agent, an analgesic agent, and combinations thereof.

### Claim 7

A medical instrument comprising:
an elongated shaft; and
a tool assembly disposed at a distal end of the elongated shaft, the tool assembly including:
an anvil assembly;
a cartridge assembly having a plurality of fasteners; and
a repository support assembly selectively engageable with at least one of the anvil assembly or the cartridge assembly, the repository support assembly having at least one implantable repository disposed thereon, wherein the at least one implantable repository is separate from the plurality of fasteners and disposed in a firing path of the plurality of fasteners, such that the at least one implantable repository is coupled to at least one of the plurality of fasteners upon firing thereof.

### Claim 8 (depends on 7)

The medical instrument according to claim 7, wherein the at least one implantable repository includes:
a capsule defining a housing having at least one enclosed lumen therein, the lumen having at least one bioactive agent disposed therein; and
at least one loop attachment member coupled to the housing, the at least one attachment member configured to couple the implantable repository to at least one of a plurality of fasteners.

### Claim 9 (depends on 8)

The medical instrument according to claim 8, wherein the housing comprises at least one biodegradable polymer.

### Claim 10 (depends on 9)

The medical instrument according to claim 9, wherein the at least one biodegradable polymer is selected from the group consisting of aliphatic polyesters, polyamides, polyamines, polyalkylene oxalates, poly(anhydrides), polyamidoesters, copoly(ether-esters), poly(carbonates), poly(hydroxyalkanoates), polyimide carbonates, poly(imino carbonates), polyorthoesters, polyoxaesters, polyphosphazenes, poly(propylene fumarates), polyurethanes, polymer drugs, protein modified bioabsorbable polymers, and combinations thereof.

### Claim 11 (depends on 8)

The medical instrument according to claim 8, wherein the at least one loop attachment member comprises a first end and a second end, wherein at least one of the first end or the second end is detachable from the housing.

### Claim 12 (depends on 8)

The medical instrument according to claim 8, wherein the at least one bioactive agent is selected from the group consisting of an anesthetic agent, an antibiotic agent, an antimicrobial agent, an anticoagulant agent, a hemostatic agent, an anti-adhesive agent, a chemotherapeutic agent, an analgesic agent, and combinations thereof.

### Claim 13 (depends on 7)

The medical instrument according to claim 7, wherein the anvil assembly is movable relative to the cartridge assembly.

### Claim 14 (depends on 13)

The medical instrument according to claim 13, wherein the anvil assembly is movable relative to the cartridge assembly along a longitudinal axis defined by the elongated shaft.

### Claim 15 (depends on 14)

The medical instrument according to claim 14, wherein the anvil assembly is rotatable relative to the cartridge assembly about a pivot axis that is perpendicular to a longitudinal axis defined by the elongated shaft.