# US 9,517,025 B2 · Analyte sensor with increased reference capacity

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- Number: US 9,517,025 B2
- Document ID: US9517025B2
- Status: Granted
- Kind: B2
- Application number: 15/153,586
- Filed: 2016-05-12
- Published: 2016-09-08
- Granted: 2016-12-13
- Earliest claimed: 2009-07-02
- Assignees: DexCom, Inc.
- Applicants: DexCom, Inc.
- Inventors: Daiting Rong; Sebastian Böhm; Matthew D. Wightlin
- Web page: https://patentgrep.com/patent/US9517025B2

## CPC

- A61B 5/14532: {for measuring glucose, e.g. by tissue impedance measurement}
- A61B 5/14865: {invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors}
- A61B 2560/0223: of calibration, e.g. protocols for calibrating sensors
- A61B 2562/0209: Special features of electrodes classified in A61B5/24, A61B5/25, A61B5/283, A61B5/291, A61B5/296, A61B5/053
- A61B 2562/043: in a linear array
- A61B 2562/125: characterised by the manufacture of electrodes
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)

## Abstract

Systems and methods of use for continuous analyte measurement of a host's vascular system are provided. In some embodiments, a continuous glucose measurement system includes an electrochemical sensor incorporating a silver/silver chloride reference electrode, wherein a capacity of the reference electrode is controlled.

## Claims

### Claim 1

An electrochemical sensor for measuring an analyte concentration in a host, comprising:
a working electrode configured to measure a concentration of an analyte; and
a reference electrode comprising a material that depletes during sensor use, wherein the material is configured to be regenerated during sensor use, and wherein a rate of material depletion during sensor use substantially correlates with a rate of material regeneration during sensor use over a time period.

### Claim 2 (depends on 1)

The electrochemical sensor of claim 1, wherein a correlation between the rate of material regeneration and the rate of material depletion is positive.

### Claim 3 (depends on 1)

The electrochemical sensor of claim 1, wherein the sensor is configured to increase the rate of material regeneration responsive to an increase in the rate of material depletion.

### Claim 4 (depends on 1)

The electrochemical sensor of claim 1, wherein the sensor is configured to decrease the rate of material regeneration responsive to a decrease in the rate of material depletion.

### Claim 5 (depends on 1)

The electrochemical sensor of claim 1, wherein at least a portion of the reference electrode is covered with an enzyme layer.

### Claim 6 (depends on 5)

The electrochemical sensor of claim 5, wherein the enzyme is an oxidase enzyme.

### Claim 7 (depends on 1)

The electrochemical sensor of claim 1, wherein the analyte is glucose.

### Claim 8 (depends on 1)

The electrochemical sensor of claim 1, wherein the material is silver chloride.

### Claim 9 (depends on 1)

The electrochemical sensor of claim 1, wherein the reference electrode is formed of a chloridized elongated silver body.

### Claim 10 (depends on 1)

The electrochemical sensor of claim 1, wherein the enzyme layer has a thickness from about 0.01 microns to about 12 microns thick.

### Claim 11 (depends on 1)

The electrochemical sensor of claim 1, wherein a percentage of a surface area of the reference electrode covered with the enzyme layer is from about 10% to about 100%.