# US 9,516,892 B2 · Use in ruminants of a food additive including a sweetener > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 9,516,892 B2 - Document ID: US9516892B2 - Status: Granted - Kind: B2 - Application number: 14/424,918 - Filed: 2013-08-29 - Published: 2015-08-13 - Granted: 2016-12-13 - Earliest claimed: 2012-08-30 - Assignees: Pancosma S.A.; The University of Liverpool - Applicants: Pancosma SA; University of Liverpool - Inventors: David Bravo; Soraya P. Shirazi-Beechey - Web page: https://patentgrep.com/patent/US9516892B2 ## CPC - A23K 20/137: containing two hetero atoms, of which at least one is nitrogen - A23K 20/10: Organic substances - A23K 20/163: Sugars; Polysaccharides - A23K 50/10: for ruminants - A61K 31/428: condensed with carbocyclic rings - A23K: FODDER - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) ## Abstract The invention concerns the use of a food additive including a sweetener in the feed or the drink of a ruminant animal to reduce the impact of stressful conditions on intestinal mucosa quality. ## Claims ### Claim 1 Method of reducing an impact of stressful conditions on intestinal mucosa quality of a ruminant animal, comprising: administering a food additive in a feed or a drink of the ruminant animal so as to reduce the impact of the stressful conditions on the intestinal mucosa quality, wherein the food additive comprises a sweetener and a potentiator. ### Claim 2 (depends on 1) Method according to claim 1, wherein the food additive improves at least one of growth, permeability, absorption, and immune functions of the intestinal mucosa. ### Claim 3 (depends on 1) Method according to claim 1, wherein the food additive is administered in case of at least one of heat stress, oxidative stress, and major feed changes, especially at weaning. ### Claim 4 (depends on 1) Method according to claim 1, wherein the food additive is administered in at least one of a preventive way and in a curative way. ### Claim 5 (depends on 4) Method according to claim 4, wherein, in a preventive way, the food additive improves intestinal mucosa quality. ### Claim 6 (depends on 4) Method according to claim 4, wherein, in a curative way, the food additive limits degradation of intestinal mucosa quality. ### Claim 7 (depends on 1) Method according to claim 1, wherein the food additive is administrated before the stressful conditions. ### Claim 8 (depends on 1) Method according to claim 1, wherein the food additive is administrated during the stressful conditions. ### Claim 9 (depends on 1) Method according to claim 1, wherein the food additive is administered to an un-weaned animal at a dose lower or equal to 400 grams of sweetener per ton of dehydrated milk replacer. ### Claim 10 (depends on 1) Method according to claim 1, wherein the food additive is administered to a weaned animal at a dose lower or equal to 200 grams of sweetener per ton of feed as dry matter. ### Claim 11 (depends on 1) Method according to claim 1, wherein the food additive is administered to a weaned animal at a dose lower or equal to 100 grams of sweetener per ton of drinking water. ### Claim 12 (depends on 1) Method according to claim 1, wherein the food additive is administered to a weaned animal at a dose lower or equal to 150 grams of sweetener per ton of feed as dry matter. ### Claim 13 (depends on 1) Method according to claim 1, wherein the food additive is administered to a weaned animal at a dose lower or equal to 75 grams of sweetener per ton of drinking water. ### Claim 14 (depends on 1) Method according to claim 1, wherein the food additive is administered to a weaned animal at a dose lower or equal to 100 grams of sweetener per ton of feed as dry matter. ### Claim 15 (depends on 1) Method according to claim 1, wherein the food additive is administered to a weaned animal at a dose lower or equal to 50 grams of sweetener per ton of drinking water. ### Claim 16 (depends on 1) Method according to claim 1, wherein the sweetener is an intense sweetener. ### Claim 17 (depends on 16) Method according to claim 16, wherein the sweetener comprises saccharin. ### Claim 18 (depends on 16) Method according to claim 16, wherein the sweetener comprises at least one compound selected from the group consisting of sodium saccharin, calcium saccharin, aspartame, acesulfame K, stevioside and cyclamate. ### Claim 19 (depends on 1) Method according to claim 1, wherein the potentiator is at least one compound selected from the group consisting of glycyrrhizin, ammonium glycyrrhizinate, potassium glycyrrhizinate, sodium glycyrrhizinate, thaumatin, kokumi, neohesperidin dihydrochalcone, ribotides and sodium glutamate. ### Claim 20 (depends on 1) Method according to claim 1, wherein the food additive comprises from 0% to 20% by weight of potentiator(s). ### Claim 21 (depends on 1) Method according to claim 1, wherein the animal is a calf.