# US 9,516,882 B2 · Cosmetic formulation

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- Number: US 9,516,882 B2
- Document ID: US9516882B2
- Status: Granted
- Kind: B2
- Application number: 15/174,244
- Filed: 2016-06-06
- Published: 2016-09-29
- Granted: 2016-12-13
- Earliest claimed: 2012-08-07
- Assignees: Pardis Kelly; Stefanie Grotkin
- Applicants: Pardis Kelly; Stefanie Grotkin
- Inventors: Pardis Kelly; Stefanie Grotkin
- Web page: https://patentgrep.com/patent/US9516882B2

## CPC

- A01N 65/36: Rutaceae [Rue family], e.g. lime, orange, lemon, corktree or pricklyash
- A01N 65/00: Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof (containing compounds of determined constitution A01N27/00 - A01N59/00)
- A61K 8/96: containing materials, or derivatives thereof of undetermined constitution
- A61K 8/9789: Magnoliopsida [dicotyledons]
- A61Q 3/02: Nail coatings
- A61Q 17/005: {Antimicrobial preparations}
- A61K 2800/43: Pigments; Dyes
- A01N: PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF (preservation of food or foodstuff A23); BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES (preparations for medical, dental or toiletry purposes which kill or prevent the growth or proliferation of unwanted organisms A61K); PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

The present invention relates generally to nail polish formulations for application to natural or artificial finger- or toenails, where the nail polish formulation comprises grapefruit seed extract that imparts antifungal and other antimicrobial properties.

## Claims

### Claim 1

A method of retarding onychomycosis in a fingernail or toenail comprising:
applying to the fingernail or toenail an antimicrobial nail polish composition comprising:
a glycerin-based grapefruit seed extract (GSE) formulation, wherein the GSE is at a concentration of from 0.05% to 0.50% (w/w) of the nail polish composition;
one or more film-forming components;
one or more solvents and/or diluents;
one or more plasticizers;
and one or more thixotropic agent, wherein said antimicrobial nail polish composition is adherent yet flexible, glossy, resists chipping and treats and/or retards onychomycosis.

### Claim 2 (depends on 1)

The method of claim 1, wherein the GSE in the antimicrobial nail polish is at a concentration of from 0.05% to 0.15% (w/w) of the nail polish composition.

### Claim 3 (depends on 2)

The method of claim 2, wherein the GSE in the antimicrobial nail polish is at a concentration of from 0.05% to 0.10% (w/w) of the nail polish composition.

### Claim 4 (depends on 1)

The method of claim 1, wherein the one or more film-forming components in the antimicrobial nail polish are selected from the group of nitrocelluloses, celluloses, vinyl polymers, ether urethanes, acetates, or polyester resins.

### Claim 5 (depends on 4)

The method of claim 4, wherein the one or more film-forming components in the antimicrobial nail polish are selected from Ecocell™ 1/2 ES (nitrocellulose/isopropyl alcohol (RS 1/2 sec)) or Ecocell™ 1/4 ES (nitrocellulose/isopropyl alcohol (RS 1/4 sec)), NX-55 (sulfonamide resin) or sucrose acetate isobutyrate.

### Claim 6 (depends on 1)

The method of claim 1, wherein the one or more plasticizers in the antimicrobial nail polish are selected from the group of castor oil, camphor, butyl glycolate, butyl stearate, triethyl citrate, dibutyl tartrate, benzyl benzoate, butyl acetyl ricinoleate, diethyl adipate, dibutyl adipate, diisobutyl adipate, dihexyl adipate, dicapryl adipate, di(2 ethyylhexyl) adipate, diisooctyl adipate, dinonyl adipate, octyl decyl adipate, isooctyl isodecyl adipate, polypropylene glycol adipate, dimethoxyethyl adipate, diethoxyethyl adipate, dibutoxyethyl adipate, dimethyl phthalate, diethyl phthalate, dipropyl phthalate, dibutyl phthalate, diisobutyl phthalate, butyl octyl phthalate, butyl isodecyl phthalate, butyl isohexyl phthalate, auryl isohexyl phthalate, dioctyl terephthalate, diisooctyl phthalate, dicaprul phthalate, di(2-ethylhexyl) phthalate, dinomyl phthalate, diethyl decyl phthalate, iso-octyl isodecyl phthalate, dodecyl phthalate, ethylhexyldecyl phthalate, butyl ethylhexyl phthalate, 2-ethlhexyl diphenyl phosphate, modified tiraryl phosphate ester, triphenyl phosphate, 2-hydroxy-4-methoxybenzophenone, non-ethyl-p-toluenesulfonamide, tricresyl phosphate, Lexorez® (polyol esterpolymer), or Lexfilm® (neopentyl glycol diheptanoate).

### Claim 7 (depends on 6)

The method of claim 6, wherein the one or more plasticizers in the antimicrobial nail polish is Lexorez® (polyol esterpolymer), Lexfilm® (neopentyl glycol diheptanoate), triphenyl phosphate, or dioctyl terephthalate.

### Claim 8 (depends on 1)

The method of claim 1, wherein the one or more thixotropic agent in the antimicrobial nail polish is a stearalkonium hectorite.

### Claim 9 (depends on 8)

The method of claim 8, wherein the stearalkonium hectorite in the antimicrobial nail polish is Bentone 27V (stearalkonium hectorite rheological additive).

### Claim 10 (depends on 1)

The method of claim 1, wherein the antimicrobial nail polish further comprises one or more pigments.

### Claim 11 (depends on 10)

The method of claim 10, wherein the pigment in the antimicrobial nail polish is formulated with nitrocellulose.

### Claim 12 (depends on 1)

The method of claim 1, wherein the antimicrobial nail polish further comprises an anti-oxidant.

### Claim 13 (depends on 1)

The method of claim 1, wherein the antimicrobial nail polish further comprises a UV-stabilizer.

### Claim 14 (depends on 1)

The method of claim 1, wherein the antimicrobial nail polish further comprises N-N′-dimethylurea.

### Claim 15 (depends on 1)

The method of claim 1, wherein the antimicrobial nail polish further comprises polydimethicone.

### Claim 16

A method of retarding onychomycosis in a fingernail or toenail comprising:
applying to the fingernail or toenail an antimicrobial nail polish composition comprising:
0.05% to 0.50% (w/w) a glycerin-based grapefruit seed extract (GSE) formulation;
one or more film-forming components selected from Ecocell™ 1/2 ES (nitrocellulose/isopropyl alcohol (RS 1/2 sec)) or Ecocell™ 1/4 ES (nitrocellulose/isopropyl alcohol (RS 1/4 sec)), NX-55 or sucrose acetate isobutyrate;
one or more solvents and/or diluents;
one or more plasticizers selected from Lexorez® (polyol esterpolymer), Lexfilm® (neopentyl glycol diheptanoate), triphenyl phosphate, or dioctyl terephthalate;
and one or more thixotropic agent, wherein said antimicrobial nail polish composition is adherent yet flexible, glossy, resists chipping and treats and/or retards onychomycosis.

### Claim 17 (depends on 16)

The method of claim 16, wherein the antimicrobial nail polish further comprises an anti-oxidant.

### Claim 18 (depends on 16)

The method of claim 16, wherein the antimicrobial nail polish further comprises a UV-stabilizer.

### Claim 19 (depends on 16)

The method of claim 16, wherein the antimicrobial nail polish further comprises N-N′-dimethylurea.

### Claim 20 (depends on 16)

The method of claim 16, wherein the antimicrobial nail polish further comprises polydimethicone.