# US 9,516,877 B2 · Antimicrobial alcohol foam compositions and methods of preparation > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 9,516,877 B2 - Document ID: US9516877B2 - Status: Granted - Kind: B2 - Application number: 14/387,989 - Filed: 2013-03-15 - Published: 2015-03-19 - Granted: 2016-12-13 - Earliest claimed: 2012-03-30 - Assignees: GOJO Industries, Inc. - Applicants: Gojo Industries, Inc. - Inventors: Mitchell Jared Cohen; James Harvey Eberts, III; Evan David Hillman - Web page: https://patentgrep.com/patent/US9516877B2 ## CPC - A01N 25/16: Foams - A01N 31/02: Acyclic compounds - A01N 37/02: Saturated carboxylic acids or thio analogues thereof; Derivatives thereof - A01N 59/00: Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds - A01N 61/00: Biocides, pest repellants or attractants, or plant growth regulators containing substances of unknown or undetermined composition, e.g. substances characterised only by the mode of action - A61K 8/046: {Aerosols; Foams} - A61K 8/19: containing inorganic ingredients - A61K 8/34: Alcohols - A61K 8/342: {Alcohols having more than seven atoms in an unbroken chain} - A61K 8/365: Hydroxycarboxylic acids; Ketocarboxylic acids - A61K 8/86: Polyethers - A61P 17/00: Drugs for dermatological disorders - A61P 31/02: Local antiseptics - A61Q 17/005: {Antimicrobial preparations} - B05B 7/0018: {with devices for making foam} - B05B 7/0408: {with arrangements for mixing two or more liquids} - B05B 7/2472: {comprising several containers} - A01N: PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF (preservation of food or foodstuff A23); BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES (preparations for medical, dental or toiletry purposes which kill or prevent the growth or proliferation of unwanted organisms A61K); PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS - A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS - B05B: SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES (spray-mixers with nozzles B01F25/72; processes for applying liquids or other fluent materials to surfaces by spraying B05D) ## Abstract A method for preparing an antimicrobial alcoholic foam composition by combining two or more pre-mix compositions. A first pre-mix composition is primarily alcoholic comprises an alcohol, an acidic component, and a waxy component. A second pre-mix composition is primarily aqueous comprises water and a carbonate. An antimicrobial alcoholic foam composition that does not require added air or aerosol propellant is also provided. ## Claims ### Claim 1 A method of preparing an antimicrobial alcoholic foam composition, the method comprising the steps of: providing a dispenser having a first reservoir containing a first liquid pre-mix that is an aqueous pre-mix, a second reservoir containing a second liquid pre-mix that is an alcoholic pre-mix; dispensing an aliquot of said aqueous pre-mix, wherein said aqueous pre-mix comprises a carbonate and water; dispensing an aliquot of said alcoholic pre-mix, wherein said alcoholic pre-mix comprises at least 50 wt. % of a C1-6 alcohol, based upon the total weight of the alcoholic pre-mix, a waxy component, and an acidic component; commingling said aliquot of said aqueous pre-mix and said aliquot of said alcoholic pre-mix, whereupon said aliquots of said aqueous pre-mix and said alcoholic pre-mix chemically react and generate an antimicrobial alcoholic foam. ### Claim 2 (depends on 1) The method of claim 1 where the acidic component is selected from the group consisting of hydrochloric acid, nitric acid, phosphoric acid, phosphonic acid, boric acid, sulfuric acid, adipic acid, benzene 1,3,5 tricarboxylic acid, chlorosuccinic acid, choline chloride, cis-aconitic acid, citramalic acid, citric acid, cyclobutane 1,1,3,3 tetracarboxylic acid, cyclohexane 1,2,4,5 tetracarboxylic acid, cyclopentane 1,2,3,4 tetracarboxylic acid, diglycolic acid, fumaric acid, glutamic acid, glutaric acid, glyoxylic acid, isocitric acid, ketomalonic acid, lactic acid, maleic acid, malic acid, malonic acid, nitrilotriacetic acid, oxalacetic acid, oxalic acid, phytic acid, p-toluenesulfonic acid, salicylic acid, succinic acid, tartaric acid, tartronic acid, tetrahydrofuran 2,3,4,5 tetracarboxylic acid, tricarballylic acid, versene acids, 3-hydroxyglutaric acid, 2-hydroxypropane 1,3 dicarboxylic acid, glyceric acid, furan 2,5 dicarboxylic acid, 3,4-dihydroxyfuran-2,5 dicarboxylic acid, 3,4-dihydroxytetrahydrofuran-2,5-dicarboxylic acid, 2-oxo-glutaric acid, dl-glyceric acid, and 2,5 furandicarboxylic acid, tartaric acid, malic acid, gluconic acid, fumaric acid, ascorbic acid, citric acid, isocitric acid, lactic acid, tartronic acid, oxalic acid, salicylic acid, malonic acid, potassium bitartrate, calcium phosphate, sodium aluminum phosphate, sodium aluminum sulfate, monosodium phosphate, disodium pyrophosphate, calcium lactate, calcium sulfate, calcium phosphate, sodium aluminum phosphate, sodium aluminum sulfate, monosodium phosphate and disodium pyrophosphate, and mixtures thereof. ### Claim 3 (depends on 1) The method of claim 1 wherein the acidic component is selected from the group consisting of citric acid, lactic acid, malic acid, tartaric acid, salicylic acid, oxalic acid, and mixtures thereof. ### Claim 4 (depends on 1) The method of claim 1 wherein the acidic component is citric acid. ### Claim 5 (depends on 1) The method of claim 1 wherein the amount of acidic component is at least 0.02 equivalent weights of acid per 100 g of combined aqueous pre-mix and alcoholic pre-mix. ### Claim 6 (depends on 1) The method of claim 1 wherein the amount of acidic component is from 0.5 to about 2 times the number of equivalent weights of carbonate present in the aqueous pre-mix. ### Claim 7 (depends on 1) The method of claim 1 wherein the amount of acidic component is the stoichiometric amount of acid required to produce at least 0.02 moles of carbon dioxide per 100 g of combined aqueous pre-mix and alcoholic pre-mix. ### Claim 8 (depends on 1) The method of claim 1 wherein the carbonate is selected from the group consisting of sodium carbonate, potassium carbonate, lithium carbonate, sodium bicarbonate, potassium bicarbonate, calcium bicarbonate, ammonium bicarbonate, and mixtures thereof. ### Claim 9 (depends on 1) The method of claim 1 wherein the carbonate is potassium bicarbonate. ### Claim 10 (depends on 1) The method of claim 1 wherein the amount of carbonate is an effective amount. ### Claim 11 (depends on 1) The method of claim 1 wherein the amount of carbonate is the stoichiometric amount of carbonate required to yield at least 0.02 moles of carbon dioxide per 100 g of combined aqueous pre-mix and alcoholic pre-mix. ### Claim 12 (depends on 1) The method of claim 1 wherein the aqueous pre-mix is a saturated solution with respect to the carbonate. ### Claim 13 (depends on 1) The method of claim 1 wherein the waxy component is selected from the group consisting of carnauba wax, ouricury wax, Japan wax, cork fiber wax, sugarcane wax, paraffin waxes, lignite waxes, microcrystalline waxes, lanolin wax, ozokerite, polyethylene wax, silicone waxes, plant waxes, C8-24 fatty alcohols, C8-24 fatty acids, glycerides that are solid at room temperature, blends of a C8-24 fatty alcohol with an ethoxylated C8-24 fatty alcohol, blends of a C8-24 fatty alcohol and a non-ionic surfactant, and mixtures thereof, with the proviso that the wax is at least sparingly soluble in a lower alcohol at standard temperature and pressure. ### Claim 14 (depends on 1) The method of claim 1 wherein the waxy component is an emulsifying wax. ### Claim 15 (depends on 1) The method of claim 1 wherein the waxy component is present in an amount of at least 0.2 wt. %, based upon the total weight of the alcoholic pre-mix. ### Claim 16 (depends on 1) The method of claim 1 wherein the waxy component is present in an amount of at least 0.1 wt. %, based upon the total weight of the combined alcoholic pre-mix and aqueous pre-mix. ### Claim 17 (depends on 1) The method of claim 1 wherein the aqueous pre-mix further comprises an emulsifier selected from the group consisting of polysorbate, polaxamer, polyethoxylated siloxane polymer, or a mixture thereof. ### Claim 18 (depends on 1) The method of claim 1 wherein the alcoholic pre-mix further comprises an emulsifier selected from the group consisting of polysorbate, poloxamer, polyethoxylated siloxane polymer, or a mixture thereof. ### Claim 19 (depends on 18) The method of claim 18 wherein the emulsifier is a poloxamer. ### Claim 20 (depends on 1) The method of claim 1 wherein the aqueous pre-mix may further comprise up to about 49 wt. % C1-6 alcohol. ### Claim 21 (depends on 1) The method of claim 1 wherein the foam expands upon the reaction of the acid and the carbonate to a final volume that is 1.5 to 5 times the combined liquid volume of the aqueous pre-mix and the alcoholic pre-mix. ### Claim 22 (depends on 1) The method of claim 1 wherein the foam is stable for at least 1 minute at room temperature and pressure. ### Claim 23 A method of preparing a non-aerosol antimicrobial alcoholic foam composition, the method comprising the steps of: providing a dispenser having a first reservoir containing a first liquid pre-mix that is an aqueous pre-mix, a second reservoir containing a second liquid pre-mix that is an alcoholic pre-mix; dispensing an aliquot of said aqueous pre-mix, wherein said aqueous pre-mix comprises a carbonate and water; dispensing an aliquot of said alcoholic pre-mix, wherein said alcoholic pre-mix comprises at least 50 wt. % of a C1-6 alcohol, based upon the total weight of the alcoholic pre-mix, a waxy component, and an acidic component; commingling said aliquot of said aqueous pre-mix and said aliquot of said alcoholic pre-mix, whereupon said aliquots of said aqueous pre-mix and said alcoholic pre-mix chemically react and generate an antimicrobial alcoholic foam; wherein the foam expands upon the reaction of the acid and the carbonate to a final volume that is 1.5 to 5 times the combined liquid volume of the aqueous pre-mix and the alcoholic pre-mix. ### Claim 24 (depends on 23) The method of claim 23, where the acidic component is selected from the group consisting of hydrochloric acid, nitric acid, phosphoric acid, phosphonic acid, boric acid, sulfuric acid, adipic acid, benzene 1,3,5 tricarboxylic acid, chlorosuccinic acid, choline chloride, cis-aconitic acid, citramalic acid, citric acid, cyclobutane 1,1,3,3 tetracarboxylic acid, cyclohexane 1,2,4,5 tetracarboxylic acid, cyclopentane 1,2,3,4 tetracarboxylic acid, diglycolic acid, fumaric acid, glutamic acid, glutaric acid, glyoxylic acid, isocitric acid, ketomalonic acid, lactic acid, maleic acid, malic acid, malonic acid, nitrilotriacetic acid, oxalacetic acid, oxalic acid, phytic acid, p-toluenesulfonic acid, salicylic acid, succinic acid, tartaric acid, tartronic acid, tetrahydrofuran 2,3,4,5 tetracarboxylic acid, tricarballylic acid, versene acids, 3-hydroxyglutaric acid, 2-hydroxypropane 1,3 dicarboxylic acid, glyceric acid, furan 2,5 dicarboxylic acid, 3,4-dihydroxyfuran-2,5 dicarboxylic acid, 3,4-dihydroxytetrahydrofuran-2,5-dicarboxylic acid, 2-oxo-glutaric acid, dl-glyceric acid, and 2,5 furandicarboxylic acid, tartaric acid, malic acid, gluconic acid, fumaric acid, ascorbic acid, citric acid, isocitric acid, lactic acid, tartronic acid, oxalic acid, salicylic acid, malonic acid, potassium bitartrate, calcium phosphate, sodium aluminum phosphate, sodium aluminum sulfate, monosodium phosphate, disodium pyrophosphate, calcium lactate, calcium sulfate, calcium phosphate, sodium aluminum phosphate, sodium aluminum sulfate, monosodium phosphate and disodium pyrophosphate, and mixtures thereof. ### Claim 25 (depends on 23) The method of claim 23, wherein the acidic component is selected from the group consisting of citric acid, lactic acid, malic acid, tartaric acid, salicylic acid, oxalic acid, and mixtures thereof. ### Claim 26 (depends on 23) The method of claim 23, wherein the acidic component is citric acid. ### Claim 27 (depends on 23) The method of claim 23, wherein the amount of acidic component is at least 0.02 equivalent weights of acid per 100 g of combined aqueous pre-mix and alcoholic pre-mix. ### Claim 28 (depends on 23) The method of claim 23, wherein the amount of acidic component is from 0.5 to about 2 times the number of equivalent weights of carbonate present in the aqueous pre-mix. ### Claim 29 (depends on 23) The method of claim 23, wherein the amount of acidic component is the stoichiometric amount of acid required to produce at least 0.02 moles of carbon dioxide per 100 g of combined aqueous pre-mix and alcoholic pre-mix. ### Claim 30 (depends on 23) The method of claim 23, wherein the carbonate is selected from the group consisting of sodium carbonate, potassium carbonate, lithium carbonate, sodium bicarbonate, potassium bicarbonate, calcium bicarbonate, ammonium bicarbonate, and mixtures thereof. ### Claim 31 (depends on 23) The method of claim 23, wherein the carbonate is potassium bicarbonate. ### Claim 32 (depends on 23) The method of claim 23, wherein the amount of carbonate is an effective amount. ### Claim 33 (depends on 23) The method of claim 23, wherein the amount of carbonate is the stoichiometric amount of carbonate required to yield at least 0.02 moles of carbon dioxide per 100 g of combined aqueous pre-mix and alcoholic pre-mix. ### Claim 34 (depends on 23) The method of claim 23, wherein the aqueous pre-mix is a saturated solution with respect to the carbonate. ### Claim 35 (depends on 23) The method of claim 23, wherein the waxy component is selected from the group consisting of carnauba wax, ouricury wax, Japan wax, cork fiber wax, sugarcane wax, paraffin waxes, lignite waxes, microcrystalline waxes, lanolin wax, ozokerite, polyethylene wax, silicone waxes, plant waxes, C8-24 fatty alcohols, C8-24 fatty acids, glycerides that are solid at room temperature, blends of a C8-24 fatty alcohol with an ethoxylated C8-24 fatty alcohol, blends of a C8-24 fatty alcohol and a non-ionic surfactant, and mixtures thereof, with the proviso that the wax is at least sparingly soluble in a lower alcohol at standard temperature and pressure. ### Claim 36 (depends on 23) The method of claim 23, wherein the waxy component is an emulsifying wax. ### Claim 37 (depends on 23) The method of claim 23, wherein the waxy component is present in an amount of at least 0.2 wt. %, based upon the total weight of the alcoholic pre-mix. ### Claim 38 (depends on 23) The method of claim 23, wherein the waxy component is present in an amount of at least 0.1 wt. %, based upon the total weight of the combined alcoholic pre-mix and aqueous pre-mix. ### Claim 39 (depends on 23) The method of claim 23, wherein the aqueous pre-mix further comprises an emulsifier selected from the group consisting of polysorbate, polaxamer, polyethoxylated siloxane polymer, or a mixture thereof. ### Claim 40 (depends on 23) The method of claim 23, wherein the alcoholic pre-mix further comprises an emulsifier selected from the group consisting of polysorbate, poloxamer, polyethoxylated siloxane polymer, or a mixture thereof. ### Claim 41 (depends on 23) The method of claim 23, wherein the emulsifier is a poloxamer. ### Claim 42 (depends on 23) The method of claim 23, wherein the aqueous pre-mix may further comprise up to about 49 wt. % C1-6 alcohol.