Interpenetrating polymer network
AssigneeUniversite Cegy-Pontoise
InventorsLaurent Bidault, Odile Fichet, Veronique Larreta Garde, Cedric Vancaeyzeele, Mathilde Hindie, Marie Deneufchatel
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Abstract
The present invention relates to a material as interpenetrating polymer network (IPN) associating a gel with a co-network of functionalized synthetic polymer and functionalized protein as well as a method of the manufacture of such a material. In particular, the invention relates to a material as interpenetrating polymer network associating a fibrin gel with a co-network of polyvinylalcohol and albumin thank to methacrylate bridges, with improved biodegradability properties.
Claims19
An interpenetrating polymer network (IPN) comprising a fibrin gel associated with a co-network of functionalized synthetic polymer cross-linked with a functionalized protein, wherein the protein is albumin functionalized with methacrylate groups and the synthetic polymer is polyvinyl alcohol (PVA) functionalized with methacrylate groups.
An interpenetrating polymer network (IPN) comprising a fibrin gel associated with a co-network of functionalized synthetic polymer cross-linked with a functionalized protein, obtained by a method comprising the steps of:
- i) preparing a first reaction mixture by introducing into a buffer:
- a. a fibrin gel forming precursor solution comprising fibrinogen or plasma,
- b. a synthetic polymer selected from the group consisting of polyvinyl alcohol (PVA), polyglycolic acid (PGA), polylactic acid (PLA), polycaprolactone (PCL), poly(N-vinylpyrrolidone), poly(2-hydroxy ethyl methacrylate) (PHEMA), polyethyleneoxide (PEO), and derivatives thereof, wherein the polymer is functionalized with grafted chemical groups X, X being selected in the group consisting of acrylate, methacrylate, vinyl, allyl and styrene and their derivatives,
- c. a serum albumin protein functionalized with grafted chemical groups X, wherein X has the same meaning as in b), and
- d. a polymerization initiator,
- ii) preparing a second reaction mixture by optionally adding a gelification activator of the formation of the fibrin gel to the first reaction mixture prepared in i),
- iii) incubating the reaction mixture obtained in i) or in ii) at a temperature and during a time sufficient to allow formation of the fibrin gel, and
- iv) performing a polymerizing and crosslinking of the functionalized synthetic polymer with the functionalized serum albumin protein.
An interpenetrating polymer network (IPN) comprising a fibrin gel associated with a co-network of functionalized synthetic polymer cross-linked with a functionalized protein, obtained by a method comprising the steps of:
- i) preparing a first reaction mixture by introducing into a buffer:
- a. a fibrinogen solution,
- b. polyvinyl alcohol (PVA) functionalized with methacrylate groups,
- c. an albumin functionalized with methacrylate groups, and
- d. a polymerization initiator,
- ii) preparing a second reaction mixture by optionally adding a gelification activator for the formation of the fibrin gel to the first reaction mixture prepared in i),
- iii) incubating the reaction mixture obtained in i) or in ii) at a temperature and during a time sufficient to allow formation of the fibrin gel,
- iv) performing a polymerizing and crosslinking of the PVA functionalized with methacrylate groups with the albumin functionalized with methacrylate groups, and
- v.) drying the material to a moisture content comprised between 2 to 10% in weight.
Dependencies are inferred from the claim text.