Proteolytic extract from bromelain for the treatment of connective tissue disorders

A method of treating a connective tissue disease comprising administering to a subject in need of such treatment a pharmaceutical composition comprising a therapeutically effective amount of a proteolytic extract obtained from bromelain and a pharmaceutically acceptable carrier, wherein the proteolytic extract comprises at least one cysteine protease selected from the group consisting of stem bromelain EC 3.4.22.32, and ananain EC 3.4.22.31, said proteolytic extract further comprises at least one cysteine protease precursor, and wherein the connective tissue disease is associated with excess collagen deposition.