High-speed wavefront optimization
AssigneeThe Regents of the University of Colorado, a body corporate
InventorsRafael Piestun, Donald Conkey
Life of this patent
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Abstract
A wavefront is optimized imaging a sample. A binary off-axis hologram is encoded by selective adoption of states for each mirror of a deformable mirror device, which is illuminated with an incident beam of light. A single diffraction order that has encoded phase-mask information is selected from light reflected from the deformable mirror device and focused onto the sample. Light scattered from the sample is directed to a photodetector. A transmission matrix through the sample is calculated from light received by the photodetector.
Claims23
A method of optimizing a wave front for imaging a sample, the method comprising:
- encoding a binary off-axis hologram by selective adoption of one of a plurality of states for each of a plurality of mirrors comprised by a deformable mirror device;
- illuminating the deformable mirror device with an incident beam of light;
- selecting a single diffraction order from light reflected from the deformable mirror device, wherein the single diffraction order comprises encoded phase-mask information;
- focusing the selected single diffraction order onto the sample;
- directing light scattered from the sample to a photodetector;
- digitizing voltage readings representing light intensity at the photodetector from the light scattered from the sample;
- calculating a transmission matrix through the sample from the digitized voltage readings;
- calculating a phase-conjugate mask from the transmission matrix;
- and
- increasing at least a portion of the voltage readings representing light intensity at the photodetector using the calculated phase-conjugate mask.
A system for optimizing a wavefront for imaging a sample, the system comprising:
- a deformable mirror device having a plurality of mirrors, each such mirror adopting one of a plurality of states to encode a binary off-axis hologram;
- a light source disposed to illuminate the deformable mirror device with an incident beam of light;
- an optical element disposed to select a single diffraction order from light reflected from the deformable mirror device, wherein the single diffraction order comprises encoded phase-mask information;
- a lens disposed to focus the selected single diffraction order onto the sample;
- a photodetector configured to digitize voltage values representing the intensity of light incident on the photodetector;
- an optical train disposed to direct light scattered from the sample to the photodetector;
- and
- a computational unit in communication with the photodetector and having instructions to calculate a transmission matrix of the system through the sample from the digitized voltage values received from the photodetector, having instructions to calculate a phase-conjugate mask from the transmission matrix, and having instructions to calculate an increase in the digitized voltage values representing light intensity at the photodetector using the calculated phase-conjugate mask.
A system comprising:
- a light source that produces a wavefront;
- a deformable mirror that modulates the wavefront produced by the light source;
- an optical system disposed to focus light reflected from the deformable mirror onto a sample through a scattering medium;
- a light sensing element disposed to digitize voltage values representing the intensity of light incident on the light sensing element;
- and
- a computational unit in communication with the light sensing element and having instructions to calculate a transmission matrix of the system through the sample from light received by the light sensing element, having instructions to calculate a phase-conjugate mask from the transmission matrix, and having instructions to increase at least a portion of the digitized voltage values representing light intensity at the light sensing element using the calculated phase-conjugate mask.
Dependencies are inferred from the claim text.